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Home / Primary Antibodies / IHC Antibodies

Anti-RAD21 Antibody BHA11301363

SKU : BHA11301363

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Mfr.No.	BS2422
Alternative Names	Double-strand-break repair protein rad21 homolog ; hHR21 ; Nuclear matrix protein 1 ; NXP-1 ; SCC1 homolog ; RAD21 ; HR21 ; KIAA0078 ; NXP1
Antigen	RAD21
Categories	Primary Antibodies
Chromosome Location	8q24.11
Clonality	polyclonal
Description	Rad21 is one of the major cohesin subunits that holds sister chromatids together until anaphase, when proteolytic cleavage by separase, a caspaselike enzyme, allows chromosomal separation. Rad21 interacts with Rec8 to form a cohesin complex that functions in sister chromatid alignment. Rad21 is also involved in the repair of double-strand breaks in DNA and is essential for mitotic growth. Rad21 undergoes a C-terminal cleavage induced by diverse stimuli right before apoptosis. The cleavage product migrates to the cytoplasm and is involved in early events in the apoptotic pathway and it amplifiies the cell death signal in a positive-feedback manner.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 521-570 of Human Rad21.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	O60216
Uniprot	O60216
Weight	130 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: Rad21 (D548) polyclonal antibody detects endogenous levels of Rad21 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC

Description

WB ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11301363	BS2422	50µl	$190.44		Add to Cart
BHA11301363	BS2422	100µl	$294.44		Add to Cart

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