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Home / Primary Antibodies / Polyclonal Antibodies

Anti-PKM2 Antibody Picoband®

SKU : BHA21000281

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Mfr.No.	PB9379, PB9379-10ug, PB9379-Biotin, PB9379-Cy3, PB9379-Dylight488, PB9379-Dylight550, PB9379-Dylight594, PB9379-FITC, PB9379-HRP, PB9379-APC, PB9379-PE, PB9379-iFluor647, PB9379-carrier-free
Alternative Names	Pyruvate kinase PKM
Background	PKM (Pyruvate Kinase, Muscle), also known as PK3 or PKM2, is an enzyme that in humans is encoded by the PKM gene. The activity of pyruvate kinase subtype M2 is increased by fructose 1, 6-bisphosphate (Fru-1, 6-P2). By in situ hybridization, Popescu and Cheng (1990) mapped the THBP1 gene to 15q24-q25. Ashizawa et al. (1991) manipulated the intracellular Fru-1, 6-P2 concentration in several mammalian cell lines, including human, by varying the glucose concentration in the media. Using a novel proteomic screen for phosphotyrosine-binding proteins, Christofk et al. (2008) observed that PKM2 binds ly and selectively to tyrosine-phosphorylated peptides.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-PKM2 Antibody Picoband® catalog # PB9379. Tested in IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ra
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human PKM2, different from the related mouse sequence by five amino acids, and from the related rat sequence by four amino acids.
Isotype	Rabbit IgG
Molecular Weight	58 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Pyruvate kinase PKM;2.7.1.40;Cytosolic thyroid hormone-binding protein;CTHBP;Opa-interacting protein 3;OIP-3;Pyruvate kinase 2/3;Pyruvate kinase muscle isozyme;Thyroid hormone-binding protein 1;THBP1;Tumor M2-PK;p58;PKM;OIP3, PK2, PK3, PKM2;
Tissue Specificity	Specifically expressed in proliferating cells, such as embryonic stem cells, embryonic carcinoma cells, as well as cancer cells. .
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	P14618
Gene Id	5315
Gene Name	PKM
Sequence	Belongs to the pyruvate kinase family.
Subcellular Location	Cytoplasm. Nucleus. Translocates to the nucleus in response to different apoptotic stimuli. Nuclear translocation is sufficient to induce cell death that is caspase independent, isoform-specific and independent of its enzymatic activity.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Human, Mouse, Rat, By Heat Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human

Reference	1. Ashizawa, K., Willingham, M. C., Liang, C.-M., Cheng, S. In vivo regulation of monomer-tetramer conversion of pyruvate kinase subtype M-2 by glucose is mediated via fructose 1, 6-bisphosphate. 2. J. Biol. Chem. 266: 16842-16846, 1991. 2. Christofk, H. R., Vander Heiden, M. G., Wu, N., Asara, J. M., Cantley, L. C. Pyruvate kinase M2 is a phosphotyrosine-binding protein. 3. Nature 452: 181-186, 2008. 3. Popescu, N. C., Cheng, S. Y. Chromosomal localization of the gene for a human cytosolic thyroid hormone binding protein homologous to the subunit of pyruvate kinase, subtype M(2). Somat. Cell Molec. Genet. 16: 593-598, 1990.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000281-1	PB9379	100 ug	-	$370		Add to Cart
BHA21000281-2	PB9379-10ug	10 ug	Sample	$99		Add to Cart
BHA21000281-3	PB9379-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000281-4	PB9379-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000281-5	PB9379-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000281-6	PB9379-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000281-7	PB9379-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000281-8	PB9379-FITC	100 ug	FITC	$570		Add to Cart
BHA21000281-9	PB9379-HRP	100 ug	HRP	$570		Add to Cart
BHA21000281-10	PB9379-APC	100 ug	APC	$670		Add to Cart
BHA21000281-11	PB9379-PE	100 ug	PE	$670		Add to Cart
BHA21000281-12	PB9379-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000281-13	PB9379-carrier-free	100 ug	carrier-free	$370		Add to Cart

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