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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Periostin/POSTN Antibody Picoband®

SKU : BHA21007263

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Mfr.No.	PA2048, PA2048-10ug, PA2048-Biotin, PA2048-Cy3, PA2048-Dylight488, PA2048-Dylight550, PA2048-Dylight594, PA2048-FITC, PA2048-HRP, PA2048-APC, PA2048-PE, PA2048-iFluor647, PA2048-carrier-free
Alternative Names	Periostin
Background	POSTN (Periostin), also known as PN or OSF2, is a protein that in humans is encoded by the POSTN gene. The Inteational Radiation Hybrid Mapping Consortium mapped the POSTN gene to chromosome 13. Gillan et al. (2002) found that purified recombinant PN supported adhesion of ovarian epithelial cells. Shao et al. (2004) found that periostin was overexpressed by the majority of human primary breast cancers examined. Transfected tumor cell lines overexpressing periostin showed accelerated growth and angiogenesis as xenografts in immunocompromised animals. Kuhn et al. (2007) showed that extracellular periostin induced reentry of differentiated mammalian cardiomyocytes into the cell cycle.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Periostin/POSTN Antibody catalog # PA2048. Tested in WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization. Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of mouse Periostin, identical to the related rat sequence, and different from the related human sequence by three amino acids.
Isotype	Rabbit IgG
Molecular Weight	93 kDa
Reactivity	Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Periostin;PN;Osteoblast-specific factor 2;OSF-2;Postn;Osf2;
Tissue Specificity	Preferentially expressed in periosteum and periodontal ligament. Also expressed in the developing and adult heart. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q62009
Gene Name	POSTN
Sequence	Contains 1 EMI domain.
Subcellular Location	Golgi apparatus. Secreted, extracellular space, extracellular matrix. Colocalizes with BMP1 in the Golgi.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Mouse, Rat<br>

Reference	1. Gillan, L., Matei, D., Fishman, D. A., Gerbin, C. S., Karlan, B. Y., Chang, D. D. Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha-V-beta-3 and alpha-V-beta-5 integrins and promotes cell motility. Cancer Res. 62: 5358-5364, 2002. <br /><br />2. Kuhn, B., del Monte, F., Hajjar, R. J., Chang, Y.-S., Lebeche, D., Arab, S., Keating, M. T. Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair. Nature Med. 13: 962-969, 2007.<br /><br />3. Shao, R., Bao, S., Bai, X., Blanchette, C., Anderson, R. M., Dang, T., Gishizky, M. L., Marks, J. R., Wang, X.-F. Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression. Molec. Cell. Biol. 24: 3992-4003, 2004.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007263-1	PA2048	-	100 ug	$370		Add to Cart
BHA21007263-2	PA2048-10ug	Sample	10 ug	$99		Add to Cart
BHA21007263-3	PA2048-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007263-4	PA2048-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007263-5	PA2048-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007263-6	PA2048-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007263-7	PA2048-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007263-8	PA2048-FITC	FITC	100 ug	$570		Add to Cart
BHA21007263-9	PA2048-HRP	HRP	100 ug	$570		Add to Cart
BHA21007263-10	PA2048-APC	APC	100 ug	$670		Add to Cart
BHA21007263-11	PA2048-PE	PE	100 ug	$670		Add to Cart
BHA21007263-12	PA2048-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007263-13	PA2048-carrier-free	carrier-free	100 ug	$370		Add to Cart

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