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Home / Primary Antibodies / Polyclonal Antibodies

Anti-PDK4 Antibody Picoband®

SKU : BHA21000675

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Mfr.No.	PB9773, PB9773-10ug, PB9773-Biotin, PB9773-Cy3, PB9773-Dylight488, PB9773-Dylight550, PB9773-Dylight594, PB9773-FITC, PB9773-HRP, PB9773-APC, PB9773-PE, PB9773-iFluor647, PB9773-carrier-free
Alternative Names	(Pyruvate dehydrogenase (acetyl-transferring)) kinase isozyme 4, mitochondrial
Background	Pyruvate dehydrogenase lipoamide kinase isozyme 4, mitochondrial is an enzyme that in humans is encoded by the PDK4 gene. This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin. In addition, PDK4 is increased in hibeation and helps to decrease metabolism and conserve glucose by decreasing its conversion to acetyl-CoA, which enters the citric acid cycle and is converted to ATP.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-PDK4 Antibody Picoband® catalog # PB9773. Tested in WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flu
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human PDK4, different from the related mouse and rat sequences by three amino acids.
Isotype	Rabbit IgG
Molecular Weight	46 kDa
Reactivity	Human, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	(Pyruvate dehydrogenase (acetyl-transferring)) kinase isozyme 4, mitochondrial;2.7.11.2;Pyruvate dehydrogenase kinase isoform 4;PDK4;PDHK4;
Tissue Specificity	Ubiquitous; highest levels of expression in heart and skeletal muscle. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q16654
Gene Id	5166
Gene Name	PDK4
Subcellular Location	Mitochondrion matrix.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Rat

Reference	1. "Entrez Gene: PDK4 pyruvate dehydrogenase kinase, isozyme 4". 2. Andrews MT, Squire TL, Bowen CM, Rollins MB (Jul 1998). "Low-temperature carbon utilization is regulated by novel gene activity in the heart of a hibeating mammal". Proceedings of the National Academy of Sciences of the United States of America 95 (14): 83927. 3. Gudi R, Bowker-Kinley MM, Kedishvili NY, Zhao Y, Popov KM (Dec 1995). "Diversity of the pyruvate dehydrogenase kinase gene family in humans".The Joual of Biological Chemistry 270 (48): 2898994.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000675-1	PB9773	100 ug	-	$370		Add to Cart
BHA21000675-2	PB9773-10ug	10 ug	Sample	$99		Add to Cart
BHA21000675-3	PB9773-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000675-4	PB9773-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000675-5	PB9773-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000675-6	PB9773-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000675-7	PB9773-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000675-8	PB9773-FITC	100 ug	FITC	$570		Add to Cart
BHA21000675-9	PB9773-HRP	100 ug	HRP	$570		Add to Cart
BHA21000675-10	PB9773-APC	100 ug	APC	$670		Add to Cart
BHA21000675-11	PB9773-PE	100 ug	PE	$670		Add to Cart
BHA21000675-12	PB9773-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000675-13	PB9773-carrier-free	100 ug	carrier-free	$370		Add to Cart

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