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Home / Primary Antibodies / Polyclonal Antibodies

Anti-PD-L1/CD274 Antibody Picoband®

SKU : BHA21000047

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Mfr.No.	PB9154, PB9154-10ug, PB9154-Biotin, PB9154-Cy3, PB9154-Dylight488, PB9154-Dylight550, PB9154-Dylight594, PB9154-FITC, PB9154-HRP, PB9154-APC, PB9154-PE, PB9154-iFluor647, PB9154-carrier-free
Alternative Names	Programmed cell death 1 ligand 1
Background	Programmed death-ligand 1 (PD-L1) also known as CD274 or B7-H1 is a protein that in humans is encoded by the CD274 gene. It is mapped to 9p24.1. PD-L1 is a 40kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the immune system during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states such as hepatitis. It has been concluded that upregulation of PD-L1 on tumor MDCs downregulates T-cell immunity and that PD-L1 blockade may represent an approach for cancer immunotherapy. PD-L1 can provide positive costimulatory signals for innate and adaptive immunity and for protection against intracellular bacterial infection. What s more, It has been found that PD1/PDL1 pathway may be a good target for restoring antitumor immunity in ovarian cancer.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-PD-L1/CD274 Antibody Picoband® catalog # PB9154. Tested in Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production. .
Host	Rabbit
Immunogen Region	E.coli-derived human PD-L1 recombinant protein (Position: E45-T290). Human PD-L1 shares 69% amino acid (aa) sequence identity with mouse PD-L1.
Isotype	Rabbit IgG
Molecular Weight	40-50 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Programmed cell death 1 ligand 1;PD-L1;PDCD1 ligand 1;Programmed death ligand 1;B7 homolog 1;B7-H1;CD274;CD274;B7H1, PDCD1L1, PDCD1LG1, PDL1;
Tissue Specificity	Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes. .
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	Q9NZQ7
Gene Id	29126
Gene Name	CD274
Sequence	Belongs to the immunoglobulin superfamily. BTN/MOG family.
Subcellular Location	Isoform 1: Cell membrane; Single-pass type I membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, WB
Description	Weste blot, 0.25-0.5ug/ml, Human Flow Cytometry (Fixed), 1-3 ug/1x10⁶ cells, Human

Reference	1. Barber, D. L., Wherry, E. J., Masopust, D., Zhu, B., Allison, J. P., Sharpe, A. H., Freeman, G. J., Ahmed, R. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439: 682-687, 2006. 2. Dong, H., Zhu, G., Tamada, K., Chen, L. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion.Nature Med. 5: 1365-1369, 1999. 3. Curiel, T. J., Wei, S., Dong, H., Alvarez, X., Cheng, P., Mottram, P., Krzysiek, R., Knutson, K. L., Daniel, B., Zimmermann, M. C., David, O., Burow, M., and 10 others. Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity. Nature Med. 9: 562-567, 2003.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000047-1	PB9154	100 ug	-	$370		Add to Cart
BHA21000047-3	PB9154-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000047-4	PB9154-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000047-5	PB9154-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000047-6	PB9154-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000047-7	PB9154-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000047-8	PB9154-FITC	100 ug	FITC	$570		Add to Cart
BHA21000047-9	PB9154-HRP	100 ug	HRP	$570		Add to Cart
BHA21000047-10	PB9154-APC	100 ug	APC	$670		Add to Cart
BHA21000047-11	PB9154-PE	100 ug	PE	$670		Add to Cart
BHA21000047-12	PB9154-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000047-13	PB9154-carrier-free	100 ug	carrier-free	$370		Add to Cart
BHA21000047-2	PB9154-10ug	10 ug	Sample	$99		Add to Cart

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