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Home / Primary Antibodies / Monoclonal Antibodies

Anti-PD-1 (S228P) Antibody

SKU : BHA18200015

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BPS Bioscience

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Mfr.No.	71326
Background	This antibody binds and blocks the activation of the PD-1 receptor. The antibody is humanized, containing a human IgG4 Fc region with an engineered hinge region mutation (S228P) designed to prevent the exchange of IgG4 molecules. This antibody is equivalent to Nivolumab, which has been approved by the FDA for the treatment of melanoma and metastatic squamous non-small cell lung cancer.
Clonality	Monoclonal
Description	Humanized recombinant anti-PD-1 (IgG4) antibody with S228P mutation, expressed in HEK293 cells. This antibody has not been tested with other species. assay conditions: Antibody was added to PD-1: PD-L1 (Biotinylated) binding assay at various concentrations. Assay was performed according to the protocol in BPS Cat. #72005 or #72006, respectively. Specific activity: IC50 = 14 nM
Formulation	8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol.
Isotype	IgG4
Molecular Weight	Heavy Chain: 50 kDa, Light Chain: 25 kDa
Species	Human
Synonyms	PD-L1 Neutralizing Antibody, Programmed Cell Death 1 Ligand 1, PD1
Tag	None
Note	Avoid freeze/thaw cycles.

Uniprot	Q15116

Format	Aqueous buffer solution.
Purification	Protein A affinity chromatographyfrom HEK293 supernatants.
Shipping Temperature	-80°C (dry ice)
Storage Stability	Stable for at least 12 months at -80°C. Store diluted antibody with carrier protein (BSA 0.1 - 0.5%) at 4°C, stable for 2 weeks.

Product Manual	Datasheet

Reference	1. Shinohara, T., et al., Genomics. 1994; 23(3): 704-6. 2. James, E.S., et al., Genes Immun. 2005; 6(5): 430-7.

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SKU	Supplier No.	Size	Your price	Quantity
BHA18200015	71326	100 ug	$539		Add to Cart

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