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Home / Primary Antibodies / Polyclonal Antibodies

Anti-PCSK9 Antibody Picoband®

SKU : BHA21007331

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Mfr.No.	PA2130, PA2130-10ug, PA2130-Biotin, PA2130-Cy3, PA2130-Dylight488, PA2130-Dylight550, PA2130-Dylight594, PA2130-FITC, PA2130-HRP, PA2130-APC, PA2130-PE, PA2130-iFluor647, PA2130-carrier-free
Alternative Names	Proprotein convertase subtilisin/kexin type 9
Background	Proprotein convertase subtilisin/kexin type 9, also known as PCSK9, is an enzyme that in humans is encoded by the PCSK9 gene. This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. By genomic sequence analysis, PCSK9 was mapped to chromosome 1p32. This gene is a crucial player in the regulation of plasma cholesterol homeostasis. It may prevent the recycling of LDLR from endosomes to the cell surface or it to lysosomes for degradation. PCSK9 can induce ubiquitination of LDLR leading to its subsequent degradation. This gene is involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-PCSK9 Antibody catalog # PA2130. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apol
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human PCSK9.
Isotype	Rabbit IgG
Molecular Weight	66 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Proprotein convertase subtilisin/kexin type 9;3.4.21.-;Neural apoptosis-regulated convertase 1;NARC-1;Proprotein convertase 9;PC9;Subtilisin/kexin-like protease PC9;PCSK9;NARC1;PSEC0052;
Tissue Specificity	Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	Q8NBP7
Gene Name	PCSK9
Sequence	Belongs to the peptidase S8 family.
Subcellular Location	Cytoplasm. Secreted. Endosome. Lysosome. Cell surface. Endoplasmic reticulum. Golgi apparatus. Autocatalytic cleavage is required to transport it from the endoplasmic reticulum to the Golgi apparatus and for the secretion of the mature protein. Localizes to the endoplasmic reticulum in the absence of LDLR and colocalizes to the cell surface and to the endosomes/lysosomes in the presence of LDLR. The sorting to the cell surface and endosomes is required in order to fully promote LDLR degradation.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br> Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Human, By Heat<br>

Reference	1. Benjannet, S., Rhainds, D., Hamelin, J., Nassoury, N., Seidah, N. G. The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications. J. Biol. Chem. 281: 30561-30572, 2006.<br /><br />2. Cohen, J. C., Boerwinkle, E., Mosley, T. H., Jr., Hobbs, H. H. Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. New Eng. J. Med. 354: 1264-1272, 2006.<br /><br />3. Kathiresan, S., Melander, O., Anevski, D., Guiducci, C., Burtt, N. P., Roos, C., Hirschho, J. N., Berglund, G., Hedblad, B., Groop, L., Altshuler, D. M., Newton-Cheh, C., Orho-Melander, M. Polymorphisms associated with cholesterol and risk of cardiovascular events. New Eng. J. Med. 358: 1240-1249, 2008.<br /><br />4. Teslovich, T. M., Musunuru, K., Smith, A. V., Edmondson, A. C., Stylianou, I. M., Koseki, M., Pirruccello, J. P., Ripatti, S., Chasman, D. I., Willer, C. J., Johansen, C. T., Fouchier, S. W., and 197 others. Biological, clinical and population relevance of 95 loci for blood lipids. Nature 466: 707-713, 2010.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007331-1	PA2130	-	100 ug	$370		Add to Cart
BHA21007331-2	PA2130-10ug	Sample	10 ug	$99		Add to Cart
BHA21007331-3	PA2130-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007331-4	PA2130-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007331-5	PA2130-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007331-6	PA2130-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007331-7	PA2130-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007331-8	PA2130-FITC	FITC	100 ug	$570		Add to Cart
BHA21007331-9	PA2130-HRP	HRP	100 ug	$570		Add to Cart
BHA21007331-10	PA2130-APC	APC	100 ug	$670		Add to Cart
BHA21007331-11	PA2130-PE	PE	100 ug	$670		Add to Cart
BHA21007331-12	PA2130-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007331-13	PA2130-carrier-free	carrier-free	100 ug	$370		Add to Cart

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