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Home / Primary Antibodies / Polyclonal Antibodies

Anti-PC1/3/PCSK1 Antibody Picoband®

SKU : BHA21007293

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Mfr.No.	PA2084, PA2084-10ug, PA2084-Biotin, PA2084-Cy3, PA2084-Dylight488, PA2084-Dylight550, PA2084-Dylight594, PA2084-FITC, PA2084-HRP, PA2084-APC, PA2084-PE, PA2084-iFluor647, PA2084-carrier-free
Alternative Names	Neuroendocrine convertase 1
Background	PCSK1 (Proprotein Convertase, Subtilisin/Kexin-Type, 1), also known as PC1 or NEC1, is an enzyme that in humans is encoded by the PCSK1 gene. Proprotein convertase-1 is a neuroendocrine convertase that belongs to a family of subtilisin-like serine endoproteases that process large precursor proteins into mature bioactive products. By in situ hybridization, Seidah et al. (1991) mapped the NEC1 gene to human chromosome 5q15-q21 and mouse chromosome 13. Ohagi et al. (1996) noted that PC1 initiates the sequential processing of proinsulin to insulin by cleaving the proinsulin molecule on the C-terminal side of the dibasic peptide, arg31-arg32, joining the B-chain and C-peptide. By observing the phenotypic features in patients with PC1 mutations, Jackson et al. (2003) concluded that human intestinal absorptive function is dependent on PC1 activity.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-PC1/3/PCSK1 Antibody catalog # PA2084. Tested in IF, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human PC1/3, identical to the related mouse and rat sequences.
Isotype	Rabbit IgG
Molecular Weight	84 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Neuroendocrine convertase 1;NEC 1;3.4.21.93;Prohormone convertase 1;Proprotein convertase 1;PC1;PCSK1;NEC1;
Tissue Specificity	Highly expressed on high endothelial venules (HEV) and lamina propia venules found in the small intestine, and to a lesser extent in the colon and spleen. Very low levels of expression found in pancreas and brain. Not expressed in the thymus, prostate, ovaries, testis, heart, placenta, lung, liver, skeletal muscle, kidney or peripheral blood leukocytes. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P29120
Gene Name	PCSK1
Sequence	Belongs to the peptidase S8 family. Furin subfamily.
Subcellular Location	Cytoplasmic vesicle, secretory vesicle. Localized in the secretion granules.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IF, IHC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat, <br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat<br> Immunofluorescence, 2ug/ml, Human

Reference	1. Jackson, R. S., Creemers, J. W. M., Farooqi, I. S., Raffin-Sanson, M.-L., Varro, A., Dockray, G. J., Holst, J. J., Brubaker, P. L., Corvol, P., Polonsky, K. S., Ostrega, D., Becker, K. L., and 10 others. Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency. J. Clin. Invest. 112: 1550-1560, 2003.<br /><br />2. Ohagi, S., Sakaguchi, H., Sanke, T., Tatsuta, H., Hanabusa, T., Nanjo, K. Human prohormone convertase 3 gene: exon-intron organization and molecular scanning for mutations in Japanese subjects with NIDDM. Diabetes 45: 897-901, 1996.<br /><br />3. Seidah, N. G., Mattei, M. G., Gaspar, L., Benjannet, S., Mbikay, M., Chretien, M. Chromosomal assignments of the genes for neuroendocrine convertase PC1 (NEC1) to human 5q15-21, neuroendocrine convertase PC2 (NEC2) to human 20p11.1-11.2, and furin (mouse 7(D1-E2) region). Genomics 11: 103-107, 1991.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007293-1	PA2084	-	100 ug	$370		Add to Cart
BHA21007293-2	PA2084-10ug	Sample	10 ug	$99		Add to Cart
BHA21007293-3	PA2084-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007293-4	PA2084-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007293-5	PA2084-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007293-6	PA2084-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007293-7	PA2084-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007293-8	PA2084-FITC	FITC	100 ug	$570		Add to Cart
BHA21007293-9	PA2084-HRP	HRP	100 ug	$570		Add to Cart
BHA21007293-10	PA2084-APC	APC	100 ug	$670		Add to Cart
BHA21007293-11	PA2084-PE	PE	100 ug	$670		Add to Cart
BHA21007293-12	PA2084-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007293-13	PA2084-carrier-free	carrier-free	100 ug	$370		Add to Cart

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