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Home / Primary Antibodies / IHC Antibodies

Anti-PAK3 Antibody BHA11302187

SKU : BHA11302187

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Mfr.No.	BS3752
Alternative Names	Serine/threonine-protein kinase PAK 3 ; Beta-PAK ; Oligophrenin-3 ; p21-activated kinase 3 ; PAK-3 ; PAK3 ; OPHN3 ; PAKβ
Antigen	PAK3
Categories	Primary Antibodies
Chromosome Location	Xq23
Clonality	polyclonal
Description	Three isoforms of serine/threonine kinases, designated αPAK p68, βPAK p65 and γPAK p62, have been shown to exhibit a high degree of sequence homology with the S. cerevisiae kinase Ste 20, involved in pheromone signaling. The α, β and γPAK isoforms complex specifically with Rac1 and Cdc42 in their active GTP-bound state, inhibiting their intrinsic GTPase activity leading to their autophosphorylation. There are eight sites of autophosphorylation on γPAK, including Ser 19, Ser 141 and Thr 402, and phosphorylation of Ser 141 and Thr 402 is correlated with γPAK activation. Once phosphorylated and their affinity for Rac/Cdc42 reduced, the PAK isoforms disassociate from the complex to seek downstream substrates.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 121-170 of Human PAK3.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	O75914
Uniprot	O75914
Weight	65 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2. Specificity: PAK3 (N148) polyclonal antibody detects endogenous levels of PAK3 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC

Description

WB ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11302187	BS3752	50µl	$190.44		Add to Cart
BHA11302187	BS3752	100µl	$294.44		Add to Cart

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