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Home / Primary Antibodies / Polyclonal Antibodies

Anti-p75 NGF Receptor/NGFR Antibody Picoband®

SKU : BHA21002674

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Mfr.No.	A01187, A01187-10ug, A01187-Biotin, A01187-Cy3, A01187-Dylight488, A01187-Dylight550, A01187-Dylight594, A01187-FITC, A01187-HRP, A01187-APC, A01187-PE, A01187-iFluor647, A01187-carrier-free
Alternative Names	nerve growth factor receptor
Background	The low-affinity nerve growth factor receptor (nerve growth factor receptor (TNFR superfamily, member 16), also called the LNGFR or p75 neurotrophin receptor) is one of the two receptor types for the neurotrophins, a family of protein growth factors that stimulate neuronal cells to survive and differentiate. LNGFR is a member of the tumor necrosis factor receptor (TNF receptor)superfamily indeed, LNGFR was the first member of this large family of receptors to be characterized. It is mapped to 17q21.33. Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-p75 NGF Receptor/NGFR Antibody Picoband® catalog # A01187. Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF. Plays an important
Host	Rabbit
Immunogen Region	E.coli-derived human p75 NGF Receptor/NGFR recombinant protein (Position: K29-Q240).
Isotype	Rabbit IgG
Molecular Weight	45 kDa, 75 kDa
Reactivity	Human, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Tumor necrosis factor receptor superfamily member 16; Gp80-LNGFR; Low affinity neurotrophin receptor P75ntr; Low-affinity nerve growth factor receptor; NGF receptor; p75 ICD; CD271; NGFR; TNFRSF16
Tissue Specificity	Expressed in peripheral leukocytes with higher expression in CD14-positive phagocytic cells. Highly expressed in keratinocytes and in periphery blood monocytes. Also detected in non-lymphoid tissues including lung and adipose tissues. Found at high levels in colorectal adenocarcinoma, Burkitt's lymphoma and chronic myelogenous leukemia.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.05mg NaN<sub>3</sub>.

Uniprot	P08138
Gene Id	4804
Gene Name	NGFR
Subcellular Location	Cell membrane. Single-pass type I membrane protein. Perikaryon. Growth cone. Dendritic spine.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB, ICC, IF, Flow Cytometry, ELISA
Description	Weste blot, 0.25-0.5ug/ml, Human, Rat<br> Immunocytochemistry/Immunofluorescence, 2ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Beattie, M. S., Harrington, A. W., Lee, R., Kim, J. Y., Boyce, S. L., Longo, F. M., Bresnahan, J. C., Hempstead, B. L., Yoon, S. O. ProNGF induces p75-mediated death of oligodendrocytes following spinal cord injury. Neuron 36: 375-386, 2002.<br /><br />2. Bentley, K. L., Ferguson-Smith, A. C., Miki, T., Kidd, K. K., Ruddle, F. H. Physical linkage of Hox 2.1 and nerve growth factor receptor. (Abstract) Cytogenet. Cell Genet. 51: 961 only, 1989.<br /><br />3. Bibel, M., Barde, Y.-A. Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system. Genes Dev. 14: 2919-2937, 2000.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002674-1	A01187	-	100 ug	$370		Add to Cart
BHA21002674-2	A01187-10ug	Sample	10 ug	$99		Add to Cart
BHA21002674-3	A01187-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002674-4	A01187-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002674-5	A01187-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002674-6	A01187-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002674-7	A01187-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002674-8	A01187-FITC	FITC	100 ug	$570		Add to Cart
BHA21002674-9	A01187-HRP	HRP	100 ug	$570		Add to Cart
BHA21002674-10	A01187-APC	APC	100 ug	$670		Add to Cart
BHA21002674-11	A01187-PE	PE	100 ug	$670		Add to Cart
BHA21002674-12	A01187-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002674-13	A01187-carrier-free	carrier-free	100 ug	$370		Add to Cart

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