This gene encodes POU5F1/Oct-4/OCT4, a transcription factor containing a POU homeodomain. This transcription factor plays a role in embryonic development, especially during early embryogenesis, and it is necessary for embryonic stem cell pluripotency. A translocation of this gene with the Ewing's sarcoma gene, t(6;22)(p21;q12), has been linked to tumor formation. Alternative splicing, as well as usage of alternative translation initiation codons, results in multiple isoforms, one of which initiates at a non-AUG (CUG) start codon. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12.
Formulation
In ascites with 0.09% sodium azide
Host
Mouse
Immunogen Region
This anti-Oct4 antibody is generated from mouse immunized with POU5F1/OCT4 recombinant protein.
Isotype
IgM
Predicted Reactivity
Human, Mouse
Reactivity
Human, Mouse
Recombinant
No
Uniprot
Q01860
Clone No
341CT7.6.2
Format
Ascites
Purification
Ascites
Storage
Aliquot the anti-Oct4 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.