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Home / Primary Antibodies / Polyclonal Antibodies

Anti-NUDT15 Antibody Picoband®

SKU : BHA21005799

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Mfr.No.	A05498-2, A05498-2-10ug, A05498-2-Biotin, A05498-2-Cy3, A05498-2-Dylight488, A05498-2-Dylight550, A05498-2-Dylight594, A05498-2-FITC, A05498-2-HRP, A05498-2-APC, A05498-2-PE, A05498-2-iFluor647, A05498-2-carrier-free
Alternative Names	Serine/threonine-protein kinase AtPK1/AtPK6
Background	Nudix hydrolase 15 is a protein that in humans is encoded by the NUDT15 gene. This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified.
Clonality	Polyclonal
Cross Reactivity	No cross reactivity with other proteins.
Description	Boster Bio Anti-NUDT15 Antibody Picoband® catalog # A05498-2. Tested in ELISA, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Downstream effector of TOR signaling pathway involved in osmotic stress response. Could be involved in the control of plant growth and development. Phosphorylates the ribosomal proteins P14, P16 and S6. Functions as a repressor of cell proliferation and r
Host	Rabbit
Immunogen Region	E.coli-derived human NUDT15 recombinant protein (Position: C23-L164). Human NUDT15 shares 90.8% amino acid (aa) sequence identity with mouse NUDT15.
Isotype	IgG
Molecular Weight	19 kDa
Reactivity	Human
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	70 kDa ribosomal protein S6 kinase 1 antibody, KS6B1_HUMAN antibody, p70 alpha antibody, P70 beta 1 antibody, p70 ribosomal S6 kinase alpha antibody, p70 ribosomal S6 kinase beta 1 antibody, p70 S6 kinase alpha antibody, P70 S6 Kinase antibody, p70 S6 kinase alpha 1 antibody, p70 S6 kinase alpha 2 antibody, p70 S6K antibody, p70 S6K-alpha antibody, p70 S6KA antibody, p70(S6K) alpha antibody, p70(S6K)-alpha antibody, p70-alpha antibody, p70-S6K 1 antibody, p70-S6K antibody, P70S6K antibody, P70S6K1 antibody, p70S6Kb antibody, PS6K antibody, Ribosomal protein S6 kinase 70kDa polypeptide 1 antibody, Ribosomal protein S6 kinase beta 1 antibody, Ribosomal protein S6 kinase beta-1 antibody, Ribosomal protein S6 kinase I antibody, RPS6KB1 antibody, S6K antibody, S6K-beta-1 antibody, S6K1 antibody, Serine/threonine kinase 14 alpha antibody, Serine/threonine-protein kinase 14A antibody, STK14A antibody
Tissue Specificity	Expressed in all tissues.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q9NV35
Gene Id	55270
Gene Name	NUDT15
Subcellular Location	Cytoplasm. Nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months.Avoid repeated freezing and thawing.

Applications	WB, ICC, IF, ELISA
Description	Weste blot, 0.25-0.5 ug/ml, Human<br> Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human<br> ELISA, 0.1-0.5 ug/ml, -<br>

Reference	1. Cai, J.-P., Ishibashi, T., Takagi, Y., Hayakawa, H., Sekiguchi, M. Mouse MTH2 protein which prevents mutations caused by 8-oxoguanine nucleotides. Biochem. Biophys. Res. Commun. 305: 1073-1077, 2003.<br /><br />2. Hartz, P. A. Personal Communication. Baltimore, Md. 5/13/2014.<br /><br />3. Moriyama, T., Nishii, R., Perez-Andreu, V., Yang, W., Klussmann, F. A., Zhao, X., Lin, T.-N., Hoshitsuki, K., Nersting, J., Kihira, K., Hofmann, U., Komada, Y., and 22 others. NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity. Nature Genet. 48: 367-373, 2016

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21005799-1	A05498-2	-	100 ug	$370		Add to Cart
BHA21005799-2	A05498-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21005799-3	A05498-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21005799-4	A05498-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21005799-5	A05498-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21005799-6	A05498-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21005799-7	A05498-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21005799-8	A05498-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21005799-9	A05498-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21005799-10	A05498-2-APC	APC	100 ug	$670		Add to Cart
BHA21005799-11	A05498-2-PE	PE	100 ug	$670		Add to Cart
BHA21005799-12	A05498-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21005799-13	A05498-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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