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Home / Primary Antibodies / IHC Antibodies

Anti-NR1I3 Antibody BHA11301302

SKU : BHA11301302

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Mfr.No.	BS2311
Alternative Names	Nuclear receptor subfamily 1 group I member 3 ; Constitutive activator of retinoid response ; Constitutive active response ; Constitutive androstane receptor ; CAR ; Orphan nuclear receptor MB67 ; NR1I3 ; CAR
Antigen	NR1I3
Categories	Primary Antibodies
Chromosome Location	1q23.3
Clonality	polyclonal
Description	This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 70-124 of Human MB67.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q14994
Uniprot	Q14994
Weight	35 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: MB67 (T102) polyclonal antibody detects endogenous levels of MB67 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

IHC

Description

IHC

Dilution

IHC	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11301302	BS2311	50µl	$190.44		Add to Cart
BHA11301302	BS2311	100µl	$294.44		Add to Cart

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