Integral membrane protein. Found in late endosomes and lysosomes.
Clonality
polyclonal
Description
Rabbit polyclonal to NPC1L1
Host
Rabbit
Immunogen
Synthetic peptide: FLEEMRAFQRRMAGM, corresponding to amino acids 596-610 of Human NPC1L1(Niemann Pick C1 Like 1).
Isotype
IgG
Quantity
100 µl
Reactivity
Human
Recombinant
FALSE
Regulatory
RUO
Shipping Condition
Ice Packs
Antigen
NPC1L1
Buffer
PBS, pH 7.4 with 0.02% sodium azide.
Concentration
1µg/ul
Description
Specificity: This Polyclonal antibody is directed against human NPC1L1 protein. The product was purified from seurm by protein A chromatography. Expect reactivity with human NPC1L1. Cross-reactivity with NPC1L1 from other sources has not been determined.Relevance: NPC1L1 encodes a deduced 1359 amino acid protein. Two alteatively spliced transcripts encode truncated proteins, one with 724 amino acids (NPC1L1T) and the other with a 27 amino acid in frame deletion (NPC1L1delE15). NPC1L1 is involved in lipid transport and the intracellular trafficking of cholesterol. NPC1L1 also has a role in diet induced hypercholesterolemia, and may play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals.
Format
Liquid
Purity
Affinity purified
Storage
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Condition
-20C
Applications
WB
Description
Recommended dilutionsWB: 1/2000.Predicted molecular weight: 145 kDa.Not yet tested in other applications.Optimal dilutions/concentrations should be determined by the end user., WB