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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Netrin receptor DCC DCC Antibody Picoband®

SKU : BHA21007156

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Mfr.No.	PA1910, PA1910-10ug, PA1910-Biotin, PA1910-Cy3, PA1910-Dylight488, PA1910-Dylight550, PA1910-Dylight594, PA1910-FITC, PA1910-HRP, PA1910-APC, PA1910-PE, PA1910-iFluor647, PA1910-carrier-free
Alternative Names	Netrin receptor DCC
Background	DCC (Deleted IN Colorectal Carcinoma) also known as CRC18 or CRCR1. The DCC gene encodes a functional receptor for netrin and mediates axon outgrowth and the steering response. Heterozygous loss-of-function mutations in DCC can result in congenital mirror movements. Alterations in DCC occur frequently in colorectal cancer. Studying a YAC contig containing the entire DCC coding region, they showed that the DCC gene spans approximately 1.4 Mb. Vogelstein (1995) stated that the precise location of the DCC gene was though to be 18q21.3. DCC is a receptor or a component of a receptor that mediates the effects of netrin-1 on commissural axons, and they complement genetic evidence for interactions between DCC and netrin homologs in C. DCC protein could be detected in varying abundance in all specimens of normal colonic mucosa analyzed as well as in all specimens of adenomatous polyps, colorectal carcinoma and colorectal liver metastases. DCC may function as a tumor-suppressor protein by inducing apoptosis in settings in which ligand is unavailable (for example, during metastasis or tumor growth beyond local blood supply) through functional caspase cascades by a mechanism that requires cleavage of DCC at asp1290. Stein et al. (2001) concluded that DCC plays a central role in netrin signaling of axon growth and guidance independent of A2B receptor activation.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Netrin receptor DCC DCC Antibody catalog # PA1910. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependen
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human DCC, identical to the related mouse sequence, and different from the related rat sequence by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	56 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Netrin receptor DCC;Colorectal cancer suppressor;Immunoglobulin superfamily DCC subclass member 1;Tumor suppressor protein DCC;DCC;IGDCC1;
Tissue Specificity	Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P43146
Gene Name	DCC
Sequence	Belongs to the immunoglobulin superfamily. DCC family.
Subcellular Location	Membrane; Single-pass type I membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br>

Reference	1. Castets, M., Broutier, L., Molin, Y., Brevet, M., Chazot, G., Gadot, N., Paquet, A., Mazelin, L., Jarroson-Wuilleme, L., Scoazec, J.-Y., Beet, A., Mehlen, P. DCC constrains tumour progression via its dependence receptor activity. Nature 482: 534-537, 2012.<br /><br />2. Stein, E., Tessier-Lavigne, M. Hierarchical organization of guidance receptors: silencing of netrin attraction by Slit through a Robo/DCC receptor complex. Science 291: 1928-1938, 2001.<br /><br />3. Vogelstein, B. Personal Communication. Baltimore, Md. 11/30/1995.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007156-1	PA1910	-	100 ug	$370		Add to Cart
BHA21007156-2	PA1910-10ug	Sample	10 ug	$99		Add to Cart
BHA21007156-3	PA1910-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007156-4	PA1910-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007156-5	PA1910-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007156-6	PA1910-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007156-7	PA1910-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007156-8	PA1910-FITC	FITC	100 ug	$570		Add to Cart
BHA21007156-9	PA1910-HRP	HRP	100 ug	$570		Add to Cart
BHA21007156-10	PA1910-APC	APC	100 ug	$670		Add to Cart
BHA21007156-11	PA1910-PE	PE	100 ug	$670		Add to Cart
BHA21007156-12	PA1910-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007156-13	PA1910-carrier-free	carrier-free	100 ug	$370		Add to Cart

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