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Home / Primary Antibodies / IHC Antibodies

Anti-NCOR1 Antibody BHA11300622

SKU : BHA11300622

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Mfr.No.	BS1462
Alternative Names	Nuclear receptor corepressor 1 ; N-CoR ; N-CoR1 ; NCOR1 ; KIAA1047
Antigen	NCOR1
Categories	Primary Antibodies
Chromosome Location	17p12-p11.2
Clonality	polyclonal
Description	Retinoids are metabolites of vitamin A (retinol) and are believed to represent important signaling molecules during vertebrate development and tissue differentiation.Two families of retinoid receptors have been identified. Retinoic acid receptors (RARs), include RARα, RARβ and RARγ, each of which have a high affinity for all-trans retinoic acids and belong to the same class of nuclear transcription factors as thyroid hormone receptors, vitamin D3 receptor and ecdysone receptor. Two cofactors that function to repress transcription, designated SMRT and N-CoR, have been shown to associate with the thyroid receptor and RAR in their unliganded state and are released from them upon ligand binding. The carboxy termini of both proteins contain receptor interacting domains while their amino termini contain two previously undescribed repressor domains. SMRT (silencing mediator for RARs and TRs) is 1495 amino acids in length with an estimated molecular weight of 168 kDa. N-CoR (nuclear receptor corepressor) is a protein 2453 amino acids in length with a relative molecular weight of 270 kDa.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 51-100 of Human N-CoR.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	O75376
Uniprot	O75376
Weight	270 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: NCoR1 (H76) polyclonal antibody detects endogenous levels of NCoR1 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC, IF

Description

WB ; IHC ; IF

Dilution

WB	1:500-1:1000
IHC	1:50-1:200
IF	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11300622	BS1462	50µl	$190.44		Add to Cart
BHA11300622	BS1462	100µl	$294.44		Add to Cart

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