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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Myosin Phosphatase/PPP1R12A Antibody Picoband®

SKU : BHA21000635

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Mfr.No.	PB9737, PB9737-10ug, PB9737-Biotin, PB9737-Cy3, PB9737-Dylight488, PB9737-Dylight550, PB9737-Dylight594, PB9737-FITC, PB9737-HRP, PB9737-APC, PB9737-PE, PB9737-iFluor647, PB9737-carrier-free
Alternative Names	Protein phosphatase 1 regulatory subunit 12A
Background	PPP1R12A (Protein phosphatase 1 regulatory subunit 12A), also called MYPT1 (Myosin phosphatase target subunit 1), is an enzyme that in humans is encoded by the PPP1R12A gene. PPP1R12A is one of the subunits of myosin phosphatase. Sequencing analysis showed that human PPP1R12A contains 1,030 amino acids with a calculated molecular mass of approximately 115 kD. The PPP1R12A gene is mapped on 12q21.2-q21.3. PPP1R12A is the protein that regulates PP1 function in smooth muscle relaxation. The cellular MYPT1-PP1-delta -specific inhibitor CPI17 caused a loss of merlin function characterized by merlin phosphorylation, Ras activation, and transformation. Jin et al. concluded that PPP1R12A and its substrate merlin are part of a previously undescribed tumor suppressor cascade that can be hindered in two ways, by mutation of the NF2 gene and by upregulation of the oncoprotein CPI17.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Myosin Phosphatase/PPP1R12A Antibody Picoband® catalog # PB9737. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN- dependent suppression of HIF1A activity. .
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human PPP1R12A, identical to the related mouse and rat sequences.
Isotype	Rabbit IgG
Molecular Weight	130 kDa
Reactivity	Human, Monkey, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Protein phosphatase 1 regulatory subunit 12A;Myosin phosphatase-targeting subunit 1;Myosin phosphatase target subunit 1;Protein phosphatase myosin-binding subunit;PPP1R12A;MBS, MYPT1;
Tissue Specificity	Expressed in striated muscles, specifically in type 2a fibers (at protein level). .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	O14974
Gene Id	4659
Gene Name	PPP1R12A
Subcellular Location	Cytoplasm . Along actomyosin filaments and stress fibers.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat, Monkey Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat Immunocytochemistry/Immunofluorescence, 2ug/ml, Human Flow Cytometry (Fixed), 1-3ug/1x10⁶ cells, Human

Reference	1. Kimura, K., Ito, M., Amano, M., Chihara, K., Fukata, Y., Nakafuku, M., Yamamori, B., Feng, J., Nakano, T., Okawa, K., Iwamatsu, A., Kaibuchi, K. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science 273: 245-248, 1996. 2. Takahashi, N., Ito, M., Tanaka, J., Nakano, T., Kaibuchi, K., Odai, H., Takemura, K. Localization of the gene coding for myosin phosphatase, target subunit 1 (MYPT1) to human chromosome 12q15-q21. Genomics 44: 150-152, 1997.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000635-1	PB9737	100 ug	-	$370		Add to Cart
BHA21000635-2	PB9737-10ug	10 ug	Sample	$99		Add to Cart
BHA21000635-3	PB9737-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000635-4	PB9737-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000635-5	PB9737-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000635-6	PB9737-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000635-7	PB9737-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000635-8	PB9737-FITC	100 ug	FITC	$570		Add to Cart
BHA21000635-9	PB9737-HRP	100 ug	HRP	$570		Add to Cart
BHA21000635-10	PB9737-APC	100 ug	APC	$670		Add to Cart
BHA21000635-11	PB9737-PE	100 ug	PE	$670		Add to Cart
BHA21000635-12	PB9737-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000635-13	PB9737-carrier-free	100 ug	carrier-free	$370		Add to Cart

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