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Home / Primary Antibodies / Polyclonal Antibodies

Anti-MTCO1/MT-CO1 Antibody Picoband®

SKU : BHA21006712

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Mfr.No.	PA1317, PA1317-10ug, PA1317-Biotin, PA1317-Cy3, PA1317-Dylight488, PA1317-Dylight550, PA1317-Dylight594, PA1317-FITC, PA1317-HRP, PA1317-APC, PA1317-PE, PA1317-iFluor647, PA1317-carrier-free
Alternative Names	Cytochrome c oxidase subunit 1
Background	Cytochrome c oxidase subunit I (CO1 or MTCO1) is 1 of 3 mitochondrial DNA (mtDNA) encoded subunits (MTCO1, MTCO2, MTCO3) of respiratory Complex IV. Complex IV is located within the mitochondrial inner membrane and is the third and final enzyme of the electron transport chain of mitochondrial oxidative phosphorylation. It is composed of 13 polypeptides. Subunits I, II, and III (MTCO1, MTCO2, MTCO3) are encoded by mtDNA while subunits IV, Va, Vb, VIa, VIb, VIc, VIIa, VIIb, VIIc, and VIII are nuclear encoded. The cytochrome c oxidase family of enzymes have 4 redox centers, 2 hemes and 2 copper centers. In mitochondrial Complex IV, the 2 hemes are a and a3 and the 2 coppers are CuA and CuB. The 2 hemes and CuB are bound to subunit I. Acin-Perez et al. (2003) identified a cell line containing single and double missense mutations in the cytochrome c oxidase (COX) subunit I gene of mouse mitochondrial DNA. And they hypothesized that deleterious mutations can arise and become predominant; cultured cells can maintain several mtDNA haplotypes at stable frequencies; the respiratory chain has little spare COX capacity; and that the size of a cavity in the vicinity of val421 in MTCO1I of animal COX may affect the function of the enzyme.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-MTCO1/MT-CO1 Antibody catalog # PA1317. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human MTCO1.
Isotype	Rabbit IgG
Molecular Weight	37 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Cytochrome c oxidase subunit 1;1.9.3.1;Cytochrome c oxidase polypeptide I;MT-CO1;COI, COXI, MTCO1;
Tissue Specificity	Neurons of the neocortex, hippocampus, piriform cortex, anterior thalamic nuclei, pontine nuclei, and granule cells of the cerebellum.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P00395
Gene Name	MT-CO1
Sequence	Belongs to the SNAP-25 family.
Subcellular Location	Mitochondrion inner membrane; Multi-pass membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Kadenbach, B.; Jarausch, J.; Hartmann, R.; Merle, P. : Separation of mammalian cytochrome c oxidase into 13 polypeptides by a sodium dodecyl sulfate-gel electrophoretic procedure. Anal. Biochem. 129: 517-521, 1983. <br /><br />2. Shoffner, J. M.; Wallace, D. C. : Oxidative phosphorylation diseases.In: Scriver, C. R.; Beaudet, A. L.; Sly, W. S.; Valle, D. (eds.) : The Metabolic and Molecular Bases of Inherited Disease. Vol. 1. New York: McGraw-Hill (7th ed.) 1995. Pp. 1535-1609. <br /><br />3. Hosler, J. P.; Ferguson-Miller, S.; Calhoun, M. W.; Thomas, J. W.; Hill, J.; Lemieux, L.; Ma, J.; Georgiou, C.; Fetter, J.; Shapleigh, J.; Tecklenburg, M. M. J.; Babcock, G. T.; Gennis, R. B. : Insight into the active-site structure and function of cytochrome oxidase by analysis of site-ed mutants of bacterial cytochrome aa3 and cytochrome bo. J. Bioenerg. Biomembr. 25: 121-136, 1993. <br /><br />4. Acin-Perez, R.; Bayona-Bafaluy, M. P.; Bueno, M.; Machicado, C.; Feandez-Silva, P.; Perez-Martos, A.; Montoya, J.; Lopez-Perez, M. J.; Sancho, J.; Enriquez, J. A. : An intragenic suppressor in the cytochrome c oxidase I gene of mouse mitochondrial DNA. Hum. Molec. Genet. 12: 329-339, 2003.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006712-1	PA1317	-	100 ug	$370		Add to Cart
BHA21006712-2	PA1317-10ug	Sample	10 ug	$99		Add to Cart
BHA21006712-3	PA1317-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006712-4	PA1317-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006712-5	PA1317-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006712-6	PA1317-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006712-7	PA1317-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006712-8	PA1317-FITC	FITC	100 ug	$570		Add to Cart
BHA21006712-9	PA1317-HRP	HRP	100 ug	$570		Add to Cart
BHA21006712-10	PA1317-APC	APC	100 ug	$670		Add to Cart
BHA21006712-11	PA1317-PE	PE	100 ug	$670		Add to Cart
BHA21006712-12	PA1317-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006712-13	PA1317-carrier-free	carrier-free	100 ug	$370		Add to Cart

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