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Home / Primary Antibodies / Polyclonal Antibodies

Anti-MRP4/ABCC4 Antibody Picoband®

SKU : BHA21000040

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Mfr.No.	PB9144, PB9144-10ug, PB9144-Biotin, PB9144-Cy3, PB9144-Dylight488, PB9144-Dylight550, PB9144-Dylight594, PB9144-FITC, PB9144-HRP, PB9144-APC, PB9144-PE, PB9144-iFluor647, PB9144-carrier-free
Alternative Names	Multidrug resistance-associated protein 4
Background	ABCC4 (Atp-binding cassette, subfamily c, member 4) also known as MRP4 or MOATB, is a protein that in humans is encoded by the ABCC4 gene. It belongs to a large family of transmembrane proteins involved in active transport of substrates out of cells. This gene is mapped to chromosome 13q32. ABCC4 acts as an independent regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP-dependent signal transduction to the nucleus. The antiproliferative effect of ABCC4 inhibition was related to cAMP-dependent PKA activation and CREB phosphorylation. Pharmacologic inhibition of ABCC4 activity or knockdown of ABCC4 via RNA interference resulted in reduced migration of DCs from human skin explants and of in vitro-generated Langerhans cells. It has been found that ABCC4 contributes to migration of DCs toward draining lymph nodes and therefore has a role in the initiation of an immune response.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-MRP4/ABCC4 Antibody Picoband® catalog # PB9144. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	May be an organic anion pump relevant to cellular detoxification.
Host	Rabbit
Immunogen Region	E.coli-derived human MRP4 recombinant protein (Position: M1-P370).
Isotype	Rabbit IgG
Molecular Weight	47 kDa
Reactivity	Rat, Mouse, Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Multidrug resistance-associated protein 4;ATP-binding cassette sub-family C member 4;MRP/cMOAT-related ABC transporter;Multi-specific organic anion transporter B;MOAT-B;ABCC4;MRP4;
Tissue Specificity	Widely expressed, with particularly high levels in prostate, but is barely detectable in liver.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	O15439
Gene Id	10257
Gene Name	ABCC4
Sequence	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Subcellular Location	Membrane; Multi-pass membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat Weste blot, 0.1-0.5ug/ml, Human

Reference	1. Kool, M., de Haas, M., Scheffer, G. L., Scheper, R. J., van Eijk, M. J., Juijn, J. A., Baas, F., Borst, P. Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. Cancer Res. 57: 3537-3547, 1997. 2. Lee, K., Belinsky, M. G., Bell, D. W., Testa, J. R., Kruh, G. D. Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter. Cancer Res. 58: 2741-2747, 1998. 3. van de Ven, R., Scheffer, G. L., Reurs, A. W., Lindenberg, J. J., Oerlemans, R., Jansen, G., Gillet, J.-P., Glasgow, J. N., Pereboev, A., Curiel, D. T., Scheper, R. J., de Gruijl, T. D. A role for multidrug resistance protein 4 (MRP4; ABCC4) in human dendritic cell migration.Blood 112: 2353-2359, 2008.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000040-1	PB9144	100 ug	-	$370		Add to Cart
BHA21000040-3	PB9144-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000040-4	PB9144-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000040-5	PB9144-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000040-6	PB9144-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000040-7	PB9144-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000040-8	PB9144-FITC	100 ug	FITC	$570		Add to Cart
BHA21000040-9	PB9144-HRP	100 ug	HRP	$570		Add to Cart
BHA21000040-10	PB9144-APC	100 ug	APC	$670		Add to Cart
BHA21000040-11	PB9144-PE	100 ug	PE	$670		Add to Cart
BHA21000040-12	PB9144-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000040-13	PB9144-carrier-free	100 ug	carrier-free	$370		Add to Cart
BHA21000040-2	PB9144-10ug	10 ug	Sample	$99		Add to Cart

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