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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Mitochondrial Pyruvate dehydrogenase kinase 1/PDK1 Antibody Picoband®

SKU : BHA21007223

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Mfr.No.	PA1993, PA1993-10ug, PA1993-Biotin, PA1993-Cy3, PA1993-Dylight488, PA1993-Dylight550, PA1993-Dylight594, PA1993-FITC, PA1993-HRP, PA1993-APC, PA1993-PE, PA1993-iFluor647, PA1993-carrier-free
Alternative Names	(Pyruvate dehydrogenase (acetyl-transferring)) kinase isozyme 1, mitochondrial
Background	PDK1 (Pyruvate Dehydrogenase Kinase Isoenzyme 1), is an enzyme that in humans is encoded by the PDK1 gene. To find human PDKs, Gudi et al. (1995) used oligonucleotide primers to screen a human liver cDNA library by PCR. They identified and reported the deduced amino acid sequences of PDK1, PDK2, and PDK3. The human PDK1 gene encodes a protein with a predicted molecular mass of 49,244 Da that shares 93% identity with that of the rat PDK1 gene. Northe blot analysis showed that the PDK1 message was expressed predominantly in the heart.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Mitochondrial Pyruvate dehydrogenase kinase 1/PDK1 Antibody catalog # PA1993. Tested in IHC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flu
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Mitochondrial Pyruvate dehydrogenase kinase 1, different from the related rat sequence by one amino acid, and from the related mouse sequence by two amino acids.
Isotype	Rabbit IgG
Molecular Weight	85-91 kDa
Reactivity	Human, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	(Pyruvate dehydrogenase (acetyl-transferring)) kinase isozyme 1, mitochondrial;2.7.11.2;Pyruvate dehydrogenase kinase isoform 1;PDH kinase 1;PDK1;PDHK1;
Tissue Specificity	Expressed predominantly in the heart. Detected at lower levels in liver, skeletal muscle and pancreas. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q15118
Gene Name	PDK1
Sequence	Belongs to the PDK/BCKDK protein kinase family.
Subcellular Location	Mitochondrion matrix .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat, By Heat <br>Weste blot, 0.1-0.5ug/ml, Human, Rat<br>

Reference	1. Gudi, R., Bowker-Kinley, M. M., Kedishvili, N. Y., Zhao, Y., Popov, K. M. Diversity of the pyruvate dehydrogenase kinase gene family in humans. J. Biol. Chem. 270: 28989-28994, 1995.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007223-1	PA1993	-	100 ug	$370		Add to Cart
BHA21007223-2	PA1993-10ug	Sample	10 ug	$99		Add to Cart
BHA21007223-3	PA1993-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007223-4	PA1993-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007223-5	PA1993-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007223-6	PA1993-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007223-7	PA1993-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007223-8	PA1993-FITC	FITC	100 ug	$570		Add to Cart
BHA21007223-9	PA1993-HRP	HRP	100 ug	$570		Add to Cart
BHA21007223-10	PA1993-APC	APC	100 ug	$670		Add to Cart
BHA21007223-11	PA1993-PE	PE	100 ug	$670		Add to Cart
BHA21007223-12	PA1993-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007223-13	PA1993-carrier-free	carrier-free	100 ug	$370		Add to Cart

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