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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Milk Fat Globule 1/MFGE8 Antibody Picoband®

SKU : BHA21007183

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Mfr.No.	PA1945, PA1945-10ug, PA1945-Biotin, PA1945-Cy3, PA1945-Dylight488, PA1945-Dylight550, PA1945-Dylight594, PA1945-FITC, PA1945-HRP, PA1945-APC, PA1945-PE, PA1945-iFluor647, PA1945-carrier-free
Alternative Names	Lactadherin
Background	MFGE8 (Milk Fat Globule-Egf Factor 8), also called as Lactadherin or SED1, is a protein which in humans is encoded by the MFGE8 gene. Mfge8 is secreted protein found in vertebrates, including mammals as well as birds. By fluorescence in situ hybridization, Collins et al. (1997) mapped the MFGE8 gene to chromosome 15q25. Hanayama et al. (2002) found that MFGE8 is a factor that links apoptotic cells to phagocytes. MFGE8 specifically bound to apoptotic cells by recognizing aminophospholipids such as phosphatidylserine. MFGE8, when engaged by phospholipids, bound to cells via its RGD motif. It bound particularly strongly to cells expressing alpha-V-beta-3 integrin. Bu et al. (2007) showed that Mfge8 was expressed in intestinal lamina propria macrophages in mice. Using a wound-healing assay, they showed that Mfge8 promoted migration of intestinal epithelial cells through a PKC-epsilon (PRKCE)-dependent mechanism.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Milk Fat Globule 1/MFGE8 Antibody catalog # PA1945. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specifi
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human Human Milk Fat Globule 1.
Isotype	Rabbit IgG
Molecular Weight	43 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Lactadherin;Breast epithelial antigen BA46;HMFG;MFGM;Milk fat globule-EGF factor 8;MFG-E8;SED1;Lactadherin short form;Medin;MFGE8;
Tissue Specificity	Mammary epithelial cell surfaces and aortic media. Overexpressed in several carcinomas.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.

Uniprot	Q08431
Gene Name	MFGE8
Sequence	Contains 1 EGF-like domain.
Subcellular Location	Membrane ; Peripheral membrane protein . Secreted .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br> Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Human, By Heat<br>

Reference	1. Bu, H.-F., Zuo, X.-L., Wang, X., Ensslin, M. A., Koti, V., Hsueh, W., Raymond, A. S., Shur, B. D., Tan, X.-D. Milk fat globule-EGF factor 8/lactadherin plays a crucial role in maintenance and repair of murine intestinal epithelium. J. Clin. Invest. 117: 3673-3683, 2007. <br /><br />2. Collins, C., Nehlin, J. O., Stubbs, J. D., Kowbel, D., Kuo, W.-L., Parry, G. Mapping of a newly discovered human gene homologous to the apoptosis associated-murine mammary protein, MFG-E8, to chromosome 15q25. Genomics 39: 117-118, 1997.<br /><br />3. Hanayama, R., Tanaka, M., Miwa, K., Shinohara, A., Iwamatsu, A., Nagata, S. Identification of a factor that links apoptotic cells to phagocytes. Nature 417: 182-187, 2002.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007183-1	PA1945	-	100 ug	$370		Add to Cart
BHA21007183-2	PA1945-10ug	Sample	10 ug	$99		Add to Cart
BHA21007183-3	PA1945-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007183-4	PA1945-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007183-5	PA1945-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007183-6	PA1945-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007183-7	PA1945-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007183-8	PA1945-FITC	FITC	100 ug	$570		Add to Cart
BHA21007183-9	PA1945-HRP	HRP	100 ug	$570		Add to Cart
BHA21007183-10	PA1945-APC	APC	100 ug	$670		Add to Cart
BHA21007183-11	PA1945-PE	PE	100 ug	$670		Add to Cart
BHA21007183-12	PA1945-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007183-13	PA1945-carrier-free	carrier-free	100 ug	$370		Add to Cart

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