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Home / Primary Antibodies / Polyclonal Antibodies

Anti-MCK10/DDR1 Antibody Picoband®

SKU : BHA21007134

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Mfr.No.	PA1878, PA1878-10ug, PA1878-Biotin, PA1878-Cy3, PA1878-Dylight488, PA1878-Dylight550, PA1878-Dylight594, PA1878-FITC, PA1878-HRP, PA1878-APC, PA1878-PE, PA1878-iFluor647, PA1878-carrier-free
Alternative Names	Epithelial discoidin domain-containing receptor 1
Background	DDR1 (Discoidin domain receptor family, member 1) also known as NEP, EDDR1, NTRK4, TRKE, DDR, CAK or RTK6, is a human gene. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen.This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain.The DDR1 gene is mapped on 6p21.33. The fibrillar collagens and immobilized collagen activated DDR1 receptor phosphorylation after prolonged treatment. Bhatt et al. (2000) showed that Ddr1 was highly expressed in the cerebellum of developing and adult mouse brain, and that both Ddr1 and collagen IV were highly expressed in the pial layer of the cerebellar cortex. Cocultures of collagen I- and IV-expressing mouse pial cells with Ddr1-expressing granule cells resulted in granule cell neurite extension. Inhibition of collagen-Ddr1signaling reduced granule cell neurite elongation.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-MCK10/DDR1 Antibody catalog # PA1878. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen bi
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human MCK10, different from the related rat sequence by one amino acid, and from the related mouse sequence by two amino acids.
Isotype	Rabbit IgG
Molecular Weight	120 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Epithelial discoidin domain-containing receptor 1;Epithelial discoidin domain receptor 1;2.7.10.1;CD167 antigen-like family member A;Cell adhesion kinase;Discoidin receptor tyrosine kinase;HGK2;Mammary carcinoma kinase 10;MCK-10;Protein-tyrosine kinase 3A;Protein-tyrosine kinase RTK-6;TRK E;Tyrosine kinase DDR;Tyrosine-protein kinase CAK;CD167a;DDR1;CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE;
Tissue Specificity	Detected in T-47D, MDA-MB-175 and HBL-100 breast carcinoma cells, A-431 epidermoid carcinoma cells, SW48 and SNU-C2B colon carcinoma cells and Hs 294T melanoma cells (at protein level). Expressed at low levels in most adult tissues and is highest in the brain, lung, placenta and kidney. Lower levels of expression are detected in melanocytes, heart, liver, skeletal muscle and pancreas. Abundant in breast carcinoma cell lines. In the colonic mucosa, expressed in epithelia but not in the connective tissue of the lamina propria. In the thyroid gland, expressed in the epithelium of the thyroid follicles. In pancreas, expressed in the islets of Langerhans cells, but not in the surrounding epithelial cells of the exocrine pancreas. In kidney, expressed in the epithelia of the distal tubules. Not expressed in connective tissue, endothelial cells, adipose tissue, muscle cells or cells of hematopoietic origin. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q08345
Gene Name	DDR1
Sequence	Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Subcellular Location	Isoform 1: Cell membrane; Single-pass type I membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Bhatt, R. S., Tomoda, T., Fang, Y., Hatten, M. E.Discoidin domain receptor 1 functions in axon extension of cerebellar granule neurons. Genes Dev. 14: 2216-2228, 2000.<br /><br />2. Edelhoff, S., Sweetser, D. A., Disteche, C. M. Mapping of the NEP receptor tyrosine kinase gene to human chromosome 6p21.3 and mouse chromosome 17C. Genomics 25: 309-311, 1995.<br /><br />3. Hou, G., Vogel, W., Bendeck, M. P. The discoidin domain receptor tyrosine kinase DDR1 in arterial wound repair. J. Clin. Invest. 107: 727-735, 2001.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007134-1	PA1878	-	100 ug	$370		Add to Cart
BHA21007134-2	PA1878-10ug	Sample	10 ug	$99		Add to Cart
BHA21007134-3	PA1878-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007134-4	PA1878-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007134-5	PA1878-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007134-6	PA1878-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007134-7	PA1878-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007134-8	PA1878-FITC	FITC	100 ug	$570		Add to Cart
BHA21007134-9	PA1878-HRP	HRP	100 ug	$570		Add to Cart
BHA21007134-10	PA1878-APC	APC	100 ug	$670		Add to Cart
BHA21007134-11	PA1878-PE	PE	100 ug	$670		Add to Cart
BHA21007134-12	PA1878-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007134-13	PA1878-carrier-free	carrier-free	100 ug	$370		Add to Cart

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