The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called 'Golli-MBP') that contains 3 additional exons located upstream of the classic MBP exons. Alteative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. (provided by RefSeq).
Formulation
In ascites with 0.09% sodium azide
Host
Mouse
Immunogen Region
Purified His-tagged protein fragment was used to produced this monoclonal anti-MBP antibody.
Isotype
IgM
Predicted Reactivity
Human
Reactivity
Human
Recombinant
No
Uniprot
P02686
Clone No
408CT17.4.3
Format
Ascites
Purification
Ascites
Storage
Aliquot the anti-MBP antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.