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Home / Primary Antibodies / Polyclonal Antibodies

Anti-LXR alpha/NR1H3 Antibody Picoband®

SKU : BHA21006699

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Mfr.No.	PA1246, PA1246-10ug, PA1246-Biotin, PA1246-Cy3, PA1246-Dylight488, PA1246-Dylight550, PA1246-Dylight594, PA1246-FITC, PA1246-HRP, PA1246-APC, PA1246-PE, PA1246-iFluor647, PA1246-carrier-free
Alternative Names	Oxysterols receptor LXR-alpha
Background	LXRA is a tissue-specific cofactor that permits RXRA to function as a potent 9cRA receptor with a distinct target gene specificity. It specifically interacts with RXRA in vivo to form a functional heterodimer in which RXRA is the ligand-binding subunit. Additionally, LXR activity is critical for physiologic lipid metabolism and transport. LXRs are endogenous inhibitors of atherogenesis and are targets for therapeutic intervention in cardiovascular disease. Furthermore, LXRs and their ligands are negative regulators of macrophage inflammatory gene expression. LXR is also found that as a transcriptional switch that integrates hepatic glucose metabolism and fatty acid synthesis. The LXR-IDOL-LDLR axis defines a complementary pathway to sterol response element-binding proteins for sterol regulation of cholesterol uptake.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-LXR alpha/NR1H3 Antibody catalog # PA1246. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Nuclear receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand- binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human LXR alpha, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	33 kDa
Reactivity	Rat, Mouse, Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Oxysterols receptor LXR-alpha;Liver X receptor alpha;Nuclear receptor subfamily 1 group H member 3;NR1H3;LXRA;
Tissue Specificity	Visceral organs specific expression. Strong expression was found in liver, kidney and intestine followed by spleen and to a lesser extent the adrenals.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q13133
Gene Name	NR1H3
Sequence	Belongs to the nuclear hormone receptor family. NR1 subfamily.
Subcellular Location	Nucleus .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. Willy, P. J.; Umesono, K.; Ong, E. S.; Evans, R. M.; Heyman, R. A.; Mangelsdorf, D. J. : LXR, a nuclear receptor that defines a distinct retinoid response pathway. Genes Dev. 9: 1033-1045, 1995. <br /><br />2. Tangirala, R. K.; Bischoff, E. D.; Joseph, S. B.; Wagner, B. L.; Walczak, R.; Laffitte, B. A.; Daige, C. L.; Thomas, D.; Heyman, R. A.; Mangelsdorf, D. J.; Wang, X.; Lusis, A. J.; Tontonoz, P.; Schulman, I. G. : Identification of macrophage liver X receptors as inhibitors of atherosclerosis. Proc. Nat. Acad. Sci. 99: 11896-11901, 2002.<br /><br />3. Joseph, S. B.; Castrillo, A.; Laffitte, B. A.; Mangelsdorf, D. J.; Tontonoz, P. : Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nature Med. 9: 213-219, 2003. <br /><br />4. Mitro, N.; Mak, P. A.; Vargas, L.; Godio, C.; Hampton, E.; Molteni, V.; Kreusch, A.; Saez, E. : The nuclear receptor LXR is a glucose sensor. Nature 445: 219-223, 2007. <br /><br />5. Zelcer, N.; Hong, C.; Boyadjian, R.; Tontonoz, P. : LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor. Science 325: 100-104, 2009.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006699-1	PA1246	-	100 ug	$370		Add to Cart
BHA21006699-2	PA1246-10ug	Sample	10 ug	$99		Add to Cart
BHA21006699-3	PA1246-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006699-4	PA1246-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006699-5	PA1246-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006699-6	PA1246-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006699-7	PA1246-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006699-8	PA1246-FITC	FITC	100 ug	$570		Add to Cart
BHA21006699-9	PA1246-HRP	HRP	100 ug	$570		Add to Cart
BHA21006699-10	PA1246-APC	APC	100 ug	$670		Add to Cart
BHA21006699-11	PA1246-PE	PE	100 ug	$670		Add to Cart
BHA21006699-12	PA1246-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006699-13	PA1246-carrier-free	carrier-free	100 ug	$370		Add to Cart

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