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Home / Primary Antibodies / Polyclonal Antibodies

Anti-L-Arginine decarboxylase/AZIN2 Antibody Picoband®

SKU : BHA21001014

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Mfr.No.	RP1112, RP1112-10ug, RP1112-Biotin, RP1112-Cy3, RP1112-Dylight488, RP1112-Dylight550, RP1112-Dylight594, RP1112-FITC, RP1112-HRP, RP1112-APC, RP1112-PE, RP1112-iFluor647, RP1112-carrier-free
Alternative Names	Antizyme inhibitor 2
Background	Antizyme inhibitor 2 (AzI2), also known as arginine decarboxylase (ADC), is an enzyme that in humans is encoded by the AZIN2 gene. The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of oithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase oithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 2, the second member of this gene family. Like antizyme inhibitor 1, antizyme inhibitor 2 interacts with all 3 antizymes and stimulates ODC activity and polyamine uptake. However, unlike antizyme inhibitor 1, which is ubiquitously expressed and localized in the nucleus and cytoplasm, antizyme inhibitor 2 is predominantly expressed in the brain and testis and localized in the endoplasmic reticulum-golgi intermediate compartment. Recent studies indicate that antizyme inhibitor 2 is also expressed in specific cell types in ovaries, adrenal glands and pancreas, and in mast cells. The exact function of this gene is not known, however, available data suggest its role in cell growth, spermiogenesis, vesicular trafficking and secretion.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-L-Arginine decarboxylase/AZIN2 Antibody catalog # RP1112. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Antizyme inhibitor protein that positively regulates oithine decarboxylase (ODC) activity and polyamine uptake by counteracting the negative effect of antizymes OAZ1, OAZ2 and OAZ3 on ODC1 activity (PubMed:17900240). Inhibits antizyme-dependent ODC1 deg
Host	Rabbit
Immunogen Region	E. coli-derived human AZIN2 recombinant protein (Position: C111-Q301). Human AZIN2 shares 89.4% amino acid (aa) sequence identity with mouse AZIN2.
Isotype	Rabbit IgG
Molecular Weight	39 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Antizyme inhibitor 2;AzI2;Arginine decarboxylase;ADC;ARGDC;Oithine decarboxylase-like protein;ODC-like protein;oithine decarboxylase paralog;ODC-p;AZIN2;ADC, KIAA1945, ODCP;
Tissue Specificity	Expressed in the neocortex, thalamus, hippocampus, cerebellum, medulla oblongata, gray and white matter. Expressed in neurons, oligodendrocytes, basket, Purkinje and pyramidal cells. Expressed in spermatocytes and Leydig cells of the testis. Expressed in luteal theca cells lining corpus luteum cysts and in hilus cells of the ovary. Expressed in primary and neoplastic mast cells (MC) (at protein level). Highly expressed in brain. Also expressed in testis. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q96A70
Gene Id	113451
Gene Name	AZIN2
Subcellular Location	Nucleus. Cytoplasm . Cytoplasm, perinuclear region. Membrane . Cytoplasmic vesicle. Endoplasmic reticulum-Golgi intermediate compartment . Golgi apparatus, cis-Golgi network . Golgi apparatus, trans-Golgi network. Cytoplasmic granule. Cell projection, axon. Cell projection, dendrite. Perikaryon. Colocalizes with KDEL receptors in ER-Golgi intermediate compartment (ERGIC). Translocates from the ERGIC structure to the cytoplasm in a antizyme-dependent manner. Localizes with vesicle- associated membrane protein VAMP8 in the vicinity of the plasma membrane within serotonin-containing secretory granules (By similarity). Detected as vesicle-like patte in neurite outgrowths. Localizes to the vesicular compartments of the secretory pathway, predominantly in the trans-Golgi network (TGN). Localizes with vesicle-associated membrane protein VAMP8 in the vicinity of the plasma membrane within serotonin-containing secretory granules. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat<br>

Reference	1. Pitkänen LT, Heiskala M, Andersson LC (2001). "Expression of a novel human oithine decarboxylase-like protein in the central nervous system and testes".Biochem. Biophys. Res. Commun. 287 (5): 10517.<br /><br />2. Zhu MY, Iyo A, Piletz JE, Regunathan S (2004). "Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatine". Biochim. Biophys. Acta1670 (2): 15664.<br /><br />

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001014-1	RP1112	100 ug	-	$370		Add to Cart
BHA21001014-2	RP1112-10ug	10 ug	Sample	$99		Add to Cart
BHA21001014-3	RP1112-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21001014-4	RP1112-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21001014-5	RP1112-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21001014-6	RP1112-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21001014-7	RP1112-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21001014-8	RP1112-FITC	100 ug	FITC	$570		Add to Cart
BHA21001014-9	RP1112-HRP	100 ug	HRP	$570		Add to Cart
BHA21001014-10	RP1112-APC	100 ug	APC	$670		Add to Cart
BHA21001014-11	RP1112-PE	100 ug	PE	$670		Add to Cart
BHA21001014-12	RP1112-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21001014-13	RP1112-carrier-free	100 ug	carrier-free	$370		Add to Cart

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