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Home / Primary Antibodies / Recombinant Antibodies

Anti-KNL1 Antibody BHA11306990

SKU : BHA11306990

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Mfr.No.	BS72177
Alternative Names	AF15Q14 ; CASC5 ; CT29 ; D40 ; MCPH4 ; PPP1R55 ; Spc7 ; hKNL-1 ; hSpc105
Categories	Primary Antibodies
Clonality	polyclonal
Description	The protein encoded by this gene is a component of the multiprotein assembly that is required for creation of kinetochore-microtubule attachments and chromosome segregation. The encoded protein functions as a scaffold for proteins that influence the spindle assembly checkpoint during the eukaryotic cell cycle and it interacts with at least five different kinetochore proteins and two checkpoint kinases. In adults, this gene is predominantly expressed in normal testes, various cancer cell lines and primary tumors from other tissues and is ubiquitously expressed in fetal tissues. This gene was originally identified as a fusion partner with the mixed-lineage leukemia (MLL) gene in t(11;15)(q23;q14). Mutations in this gene cause autosomal recessive primary microcephaly-4 (MCPH4). Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described but their biological validity has not been confirmed.
Host	Rabbit
Immunogen	Recombinant Protein of human CASC5
Reactivity	Human
Recombinant	TRUE
Regulatory	RUO

Swissprot	Q8NG31
Uniprot	Q8NG31
Weight	300kDa

Description	Product: 1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol. Specificity: CASC5 polyclonal antibody detects endogenous levels of CASC5 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:2000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11306990	BS72177	50µl	$234.89		Add to Cart
BHA11306990	BS72177	100µl	$368.22		Add to Cart

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