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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Integrin beta 1/ITGB1 Antibody Picoband®

SKU : BHA21007537

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Mfr.No.	PB9086, PB9086-10ug, PB9086-Biotin, PB9086-Cy3, PB9086-Dylight488, PB9086-Dylight550, PB9086-Dylight594, PB9086-FITC, PB9086-HRP, PB9086-APC, PB9086-PE, PB9086-iFluor647, PB9086-carrier-free
Alternative Names	Integrin beta-1
Background	Integrin beta-1, also known as CD29, is a protein that in humans is encoded by the ITGB1 gene. CD29 is an integrin unit associated with very late antigen receptors. It is known to conjoin with alpha-3 subunit to create alpha3beta1 complex that reacts to such molecules as netrin-1 and reelin. This gene contains a beta subunit that appears to be analogous to band-3 of integrin. It is mapped to 10p11.22. It is found that FER mediates crosstalk between CDH2 and CD29. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. The protein encoded by this gene is a beta subunit.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Integrin beta 1/ITGB1 Antibody Picoband® catalog # PB9086. Tested in IHC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta- 1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha- 1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha- 3
Host	Rabbit
Immunogen Region	E.coli-derived human ITGB1 recombinant protein (Position: N527-D728). Human ITGB1 shares 91% and 88% amino acid (aa) sequences identity with mouse and rat ITGB1, respectively.
Isotype	Rabbit IgG
Molecular Weight	120-130 kDa
Reactivity	Human, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Integrin beta-1;Fibronectin receptor subunit beta;Glycoprotein IIa;GPIIA;VLA-4 subunit beta;CD29;ITGB1;FNRB, MDF2, MSK12;
Tissue Specificity	Isoform 1 is widely expressed, other isoforms are generally coexpressed with a more restricted distribution. Isoform 2 is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbilical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoform 3 and isoform 4 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform 4, rather than isoform 3, is selectively expressed in peripheral T-cells. Isoform 3 is expressed in non- proliferating and differentiated prostate gland epithelial cells and in platelets, on the surface of erythroleukemia cells and in various hematopoietic cell lines. Isoform 5 is expressed specifically in striated muscle (skeletal and cardiac muscle). .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P05556
Gene Id	3688
Gene Name	ITGB1
Sequence	Belongs to the integrin beta chain family.
Subcellular Location	Cell membrane ; Single-pass type I membrane protein . Cell projection, invadopodium membrane ; Single-pass type I membrane protein . Cell projection, ruffle membrane ; Single- pass type I membrane protein . Recycling endosome. Melanosome. Cleavage furrow. Cell projection, lamellipodium. Cell projection, ruffle. Isoform 2 does not localize to focal adhesions. Highly enriched in stage I melanosomes. Located on plasma membrane of neuroblastoma NMB7 cells. In a lung cancer cell line, in prometaphase and metaphase, localizes diffusely at the membrane and in a few intracellular vesicles. In early telophase, detected mainly on the matrix-facing side of the cells. By mid- telophase, concentrated to the ingressing cleavage furrow, mainly to the basal side of the furrow. In late telophase, concentrated to the extending protrusions formed at the opposite ends of the spreading daughter cells, in vesicles at the base of the lamellipodia formed by the separating daughter cells. Colocalizes with ITGB1BP1 and metastatic suppressor protein NME2 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen. Translocates from peripheral focal adhesions sites to fibrillar adhesions in a ITGB1BP1-dependent manner. Enriched preferentially at invadopodia, cell membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. Localized at plasma and ruffle membranes in a collagen-independent manner. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Rat Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat

Reference	1. Goodfellow PJ, Nevanlinna HA, Gorman P, Sheer D, Lam G, Goodfellow PN (July 1989). "Assignment of the gene encoding the beta-subunit of the human fibronectin receptor (beta-FNR) to chromosome 10p11.2". Ann Hum Genet53 (Pt 1): 1522. 2. Pytela, R., Pierschbacher, M. D., Ginsberg, M. H., Plow, E. F., Ruoslahti, E. Platelet membrane glycoprotein IIb/IIIa: member of a family of arg-gly-asp-specific adhesion receptors. Science 231: 1159-1162, 1986.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007537-1	PB9086	-	100 ug	$370		Add to Cart
BHA21007537-2	PB9086-10ug	Sample	10 ug	$99		Add to Cart
BHA21007537-3	PB9086-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007537-4	PB9086-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007537-5	PB9086-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007537-6	PB9086-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007537-7	PB9086-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007537-8	PB9086-FITC	FITC	100 ug	$570		Add to Cart
BHA21007537-9	PB9086-HRP	HRP	100 ug	$570		Add to Cart
BHA21007537-10	PB9086-APC	APC	100 ug	$670		Add to Cart
BHA21007537-11	PB9086-PE	PE	100 ug	$670		Add to Cart
BHA21007537-12	PB9086-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007537-13	PB9086-carrier-free	carrier-free	100 ug	$370		Add to Cart

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