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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Insulin Receptor/INSR Antibody Picoband®

SKU : BHA21000977

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Mfr.No.	PB10072, PB10072-10ug, PB10072-Biotin, PB10072-Cy3, PB10072-Dylight488, PB10072-Dylight550, PB10072-Dylight594, PB10072-FITC, PB10072-HRP, PB10072-APC, PB10072-PE, PB10072-iFluor647, PB10072-carrier-free
Alternative Names	Insulin receptor
Background	INSR (INSULIN RECEPTOR) is a tetramer of 2 alpha and 2 beta subunits that are coded by a single gene and are joined by disulfide bonds, a mechanism parallel to that of its ligand, insulin. It belongs to the large class of tyrosine kinase receptors. The insulin receptor gene is mapped to 19p13.2. The insulin receptor mediates their activity by causing the addition of a phosphate group to particular tyrosines on certain proteins within a cell. The INSR gene spans more than 120 kb and has 22 exons. Functional studies of the INSR SNPs show no effect on mRNA levels or splicing in peripheral blood leukocytes or on binding of insulin to mononuclear cells.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Insulin Receptor/INSR Antibody Picoband® catalog # PB10072. Tested in WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling interme
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human Insulin Receptor, identical to the related mouse and rat sequences.
Isotype	Rabbit IgG
Molecular Weight	155 kDa
Reactivity	Human, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Insulin receptor;IR;2.7.10.1;CD220;Insulin receptor subunit alpha;Insulin receptor subunit beta;INSR;
Tissue Specificity	Isoform Long and isoform Short are predominantly expressed in tissue targets of insulin metabolic effects: liver, adipose tissue and skeletal muscle but are also expressed in the peripheral nerve, kidney, pulmonary alveoli, pancreatic acini, placenta vascular endothelium, fibroblasts, monocytes, granulocytes, erythrocytes and skin. Isoform Short is preferentially expressed in fetal cells such as fetal fibroblasts, muscle, liver and kidney. Found as a hybrid receptor with IGF1R in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Overexpressed in several tumors, including breast, colon, lung, ovary, and thyroid carcinomas. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P06213
Gene Id	3643
Gene Name	INSR
Subcellular Location	Cell membrane; Single-pass type I membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Rat

Reference	1. Accili, D., Drago, J., Lee, E. J., Johnson, M. D., Cool, M. H., Salvatore, P., Asico, L. D., Jose, P. A., Taylor, S. I., Westphal, H. Early neonatal death in mice homozygous for a null allele of the insulin receptor gene. Nature Genet. 12: 106-109, 1996. 2. 't Hart, L. M., Stolk, R. P., Dekker, J. M., Nijpels, G., Grobbee, D. E., Heine, R. J., Maassen, J. A. Prevalence of variants in candidate genes for type 2 diabetes mellitus in the Netherlands: the Rotterdam study and the Hoo study. J. Clin. Endocr. Metab. 84: 1002-1006, 1999. 3. Ward CW, Lawrence MC (April 2009). "Ligand-induced activation of the insulin receptor: a multi-step process involving structural changes in both the ligand and the receptor".

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000977-1	PB10072	100 ug	-	$370		Add to Cart
BHA21000977-2	PB10072-10ug	10 ug	Sample	$99		Add to Cart
BHA21000977-3	PB10072-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000977-4	PB10072-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000977-5	PB10072-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000977-6	PB10072-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000977-7	PB10072-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000977-8	PB10072-FITC	100 ug	FITC	$570		Add to Cart
BHA21000977-9	PB10072-HRP	100 ug	HRP	$570		Add to Cart
BHA21000977-10	PB10072-APC	100 ug	APC	$670		Add to Cart
BHA21000977-11	PB10072-PE	100 ug	PE	$670		Add to Cart
BHA21000977-12	PB10072-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000977-13	PB10072-carrier-free	100 ug	carrier-free	$370		Add to Cart

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