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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Indoleamine 2, 3-dioxygenase/IDO1 Antibody Picoband®

SKU : BHA21006925

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Mfr.No.	PA1611, PA1611-10ug, PA1611-Biotin, PA1611-Cy3, PA1611-Dylight488, PA1611-Dylight550, PA1611-Dylight594, PA1611-FITC, PA1611-HRP, PA1611-APC, PA1611-PE, PA1611-iFluor647, PA1611-carrier-free
Alternative Names	Indoleamine 2,3-dioxygenase 1
Background	IDO1 (INDOLEAMINE 2,3-DIOXYGENASE), INDO or IDO, is an immunomodulatory enzyme produced by some alteatively activated macrophages and other immunoregulatory cells. This enzyme catalyzes the degradation of the essential amino acid L-tryptophan to N-formyl-kynurenine. By fluorescence in situ hybridization, the assignment is narrowed to chromosome 8p12-p11. INDO Interferon-gamma has an antiproliferative effect on many tumor cells and inhibits intracellular pathogens such as Toxoplasma and chlamydia, at least partly because of the induction of indoleamine 2,3-dioxygenase. During inflammation, IDO is upregulated in dendritic cells and phagocytes by proinflammatory stimuli, most notably IFNG, and the enzyme then uses superoxide as a 'cofactor' for oxidative cleavage of the indole ring of tryptophan, yielding an intermediate that deformylates to L-kynurenine.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Indoleamine 2, 3-dioxygenase/IDO1 Antibody catalog # PA1611. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen. .
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human IDO1.
Isotype	Rabbit IgG
Molecular Weight	45 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Indoleamine 2,3-dioxygenase 1;IDO-1;1.13.11.52;Indoleamine-pyrrole 2,3-dioxygenase;IDO1;IDO, INDO;
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P14902
Gene Name	IDO1
Sequence	Belongs to the indoleamine 2,3-dioxygenase family.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Burkin, D. J., Kimbro, K. S., Barr, B. L., Jones, C., Taylor, M. W., Gupta, S. L. Localization of the human indoleamine 2,3-dioxygenase (IDO) gene to the pericentromeric region of human chromosome 8. Genomics 17: 262-263, 1993. <br /><br />2. Dai, W., Gupta, S. L. Molecular cloning, sequencing and expression of human interferon-gamma-inducible indoleamine 2,3-dioxygenase cDNA. Biochem. Biophys. Res. Commun. 168: 1-8, 1990. <br /><br />3. Fallarino, F., Grohmann, U., Hwang, K. W., Orabona, C., Vacca, C., Bianchi, R., Belladonna, M. L., Fioretti, M. C., Alegre, M.-L., Puccetti, P. Modulation of tryptophan catabolism by regulatory T cells. Nature Immun. 4: 1206-1212, 2003.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006925-1	PA1611	-	100 ug	$370		Add to Cart
BHA21006925-2	PA1611-10ug	Sample	10 ug	$99		Add to Cart
BHA21006925-3	PA1611-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006925-4	PA1611-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006925-5	PA1611-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006925-6	PA1611-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006925-7	PA1611-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006925-8	PA1611-FITC	FITC	100 ug	$570		Add to Cart
BHA21006925-9	PA1611-HRP	HRP	100 ug	$570		Add to Cart
BHA21006925-10	PA1611-APC	APC	100 ug	$670		Add to Cart
BHA21006925-11	PA1611-PE	PE	100 ug	$670		Add to Cart
BHA21006925-12	PA1611-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006925-13	PA1611-carrier-free	carrier-free	100 ug	$370		Add to Cart

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