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Home / Primary Antibodies / Polyclonal Antibodies

Anti-IGFBP3 Antibody Picoband®

SKU : BHA21006841

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Mfr.No.	PA1498, PA1498-10ug, PA1498-Biotin, PA1498-Cy3, PA1498-Dylight488, PA1498-Dylight550, PA1498-Dylight594, PA1498-FITC, PA1498-HRP, PA1498-APC, PA1498-PE, PA1498-iFluor647, PA1498-carrier-free
Alternative Names	Insulin-like growth factor-binding protein 3
Background	IGFBP3, Insulin-like growth fator-binding protein 3, is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. IGFBP3 is located on chromosome 7. The protein forms a teary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alteate transcriptional splice variants, encoding different isoforms, have been characterized.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-IGFBP3 Antibody catalog # PA1498. Tested in WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-ind
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human IGFBP-3.
Isotype	Rabbit IgG
Molecular Weight	40 kDa
Reactivity	Human, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Insulin-like growth factor-binding protein 3;IBP-3;IGF-binding protein 3;IGFBP-3;IGFBP3;IBP3;
Tissue Specificity	Expressed by most tissues. Present in plasma.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P17936
Gene Name	IGFBP3
Sequence	Contains 1 IGFBP N-terminal domain.
Subcellular Location	Secreted .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Rat<br>

Reference	1. Lofqvist, C., Chen, J., Connor, K. M., Smith, A. C. H., Aderman, C. M., Liu, N., Pintar, J. E., Ludwig, T., Hellstrom, A., Smith, L. E. H. IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth.Proc. Nat. Acad. Sci. 104: 10589-10594, 2007.<br /><br />2. Nwosu BU, et al. Evidence of insulin-like growth factor binding protein-3 proteolysis during growth hormone stimulation testing. J Pediatr Endocrinol Metab, 2011.<br /><br />3. Relationship of insulin-like growth factor (IGF) binding protein-3 (IGFBP-3) gene polymorphism with the susceptibility to development of prostate cancer and influence on serum levels of IGF-I, and IGFBP-3. Safarinejad MR, et al. Growth Horm IGF Res, 2011 Jun.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006841-1	PA1498	-	100 ug	$370		Add to Cart
BHA21006841-2	PA1498-10ug	Sample	10 ug	$99		Add to Cart
BHA21006841-3	PA1498-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006841-4	PA1498-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006841-5	PA1498-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006841-6	PA1498-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006841-7	PA1498-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006841-8	PA1498-FITC	FITC	100 ug	$570		Add to Cart
BHA21006841-9	PA1498-HRP	HRP	100 ug	$570		Add to Cart
BHA21006841-10	PA1498-APC	APC	100 ug	$670		Add to Cart
BHA21006841-11	PA1498-PE	PE	100 ug	$670		Add to Cart
BHA21006841-12	PA1498-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006841-13	PA1498-carrier-free	carrier-free	100 ug	$370		Add to Cart

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