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Home / Primary Antibodies / Polyclonal Antibodies

Anti-ICAM1 Antibody Picoband®

SKU : BHA21007480

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Mfr.No.	PB9017, PB9017-10ug, PB9017-Biotin, PB9017-Cy3, PB9017-Dylight488, PB9017-Dylight550, PB9017-Dylight594, PB9017-FITC, PB9017-HRP, PB9017-APC, PB9017-PE, PB9017-iFluor647, PB9017-carrier-free
Alternative Names	Intercellular adhesion molecule 1
Background	Intercellular adhesion molecule-1 (ICAM-1) is an integral membrane protein, a member of the immunoglobulin superfamily, and a ligand for lymphocyte function-associated (LFA) antigens, a beta 2 leukocyte integrin. The normal function of human ICAM-1 is to provide adhesion between endothelial cells and leukocytes after injury or stress. ICAM-1 binds to leukocyte function-associated antigen (LFA-1) or macrophage-1 antigen (Mac-1). It is found on leukocytes, fibroblasts, epithelial cells and endothelial cells and its expression is regulated by inflammatory cytokines. ICAM-1 has a tissue distribution similar to that of the major histocompatibility complex class II antigens and is likely to play a role in inflammatory responses.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-ICAM1 Antibody Picoband® catalog # PB9017. Tested in Flow Cytometry, IF, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans- endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In ca
Host	Rabbit
Immunogen Region	E.coli-derived human ICAM1 recombinant protein (Position: L214-P532). Human ICAM1 shares 52% and 48% amino acid (aa) sequences identity with mouse and rat ICAM1, respectively.
Isotype	Rabbit IgG
Molecular Weight	100 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Intercellular adhesion molecule 1;ICAM-1;Major group rhinovirus receptor;CD54;ICAM1;
Tissue Specificity	Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P05362
Gene Id	3383
Gene Name	ICAM1
Sequence	Belongs to the immunoglobulin superfamily. ICAM family.
Subcellular Location	Membrane; Single-pass type I membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, IHC-F, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat<br> Immunohistochemistry (Frozen Section), 0.5-1ug/ml, Human<br> Immunocytochemistry, 0.5-1ug/ml, Human<br> Immunofluorescence, 2ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human

Reference	1. Ballantyne, C. M.; Kozak, C. A.; O'Brien, W. E.; Beaudet, A. L. Assignment of the gene for intercellular adhesion molecule-1 (Icam-1) to proximal mouse chromosome 9. Genomics 9: 547-550, 1991. <br /><br />2. Bella, J.; Kolatkar, P. R.; Marlor, C. W.; Greve, J. M.; Rossmann, M. G. The structure of the two amino-terminal domains of human ICAM-1 suggests how it functions as a rhinovirus receptor and as an LFA-1 integrin ligand. Proc. Nat. Acad. Sci. 95: 4140-4145, 1998. <br /><br />3. Simmons, D.; Makgoba, M. W.; Seed, B. ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM. Nature 331: 624-627, 1988. <br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007480-1	PB9017	-	100 ug	$370		Add to Cart
BHA21007480-2	PB9017-10ug	Sample	10 ug	$99		Add to Cart
BHA21007480-3	PB9017-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007480-4	PB9017-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007480-5	PB9017-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007480-6	PB9017-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007480-7	PB9017-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007480-8	PB9017-FITC	FITC	100 ug	$570		Add to Cart
BHA21007480-9	PB9017-HRP	HRP	100 ug	$570		Add to Cart
BHA21007480-10	PB9017-APC	APC	100 ug	$670		Add to Cart
BHA21007480-11	PB9017-PE	PE	100 ug	$670		Add to Cart
BHA21007480-12	PB9017-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007480-13	PB9017-carrier-free	carrier-free	100 ug	$370		Add to Cart

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