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Home / Primary Antibodies / Polyclonal Antibodies

Anti-HP1 gamma/CBX3 Antibody Picoband®

SKU : BHA21001489

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Mfr.No.	A01142, A01142-10ug, A01142-Biotin, A01142-Cy3, A01142-Dylight488, A01142-Dylight550, A01142-Dylight594, A01142-FITC, A01142-HRP, A01142-APC, A01142-PE, A01142-iFluor647, A01142-carrier-free
Alternative Names	chromobox 3
Background	Chromobox protein homolog 3 is a protein that is encoded by the CBX3 gene in humans. At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-HP1 gamma/CBX3 Antibody Picoband® catalog # A01142. Tested in ELISA, Flow Cytometry, IF, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuc
Host	Rabbit
Immunogen Region	E. coli-derived human HP1 gamma recombinant protein (Position: A2-Q183).
Isotype	Rabbit IgG
Molecular Weight	21 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Chromobox protein homolog 3; HECH; Heterochromatin protein 1 homolog gamma; HP1 gamma; Modifier 2 protein; CBX3
Tissue Specificity	Widely expressed. Expressed at the highest levels in pancreas, heart, brain, skeletal muscle and placenta. Expressed at lower levels in lung, liver and kidney.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.05mg NaN<sub>3</sub>.

Uniprot	Q13185
Gene Id	11335
Gene Name	CBX3
Subcellular Location	Nucleus . Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis (Potential).

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, Flow Cytometry, IF, IHC, IHC-F, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat<br> Immunohistochemistry (Frozen Section), 0.5-1ug/ml, Human, Mouse, Rat<br> Immunocytochemistry/Immunofluorescence, 2ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. "Entrez Gene: CBX3 chromobox homolog 3 (HP1 gamma homolog, Drosophila)".<br /><br />2. Koike, N; Maita H; Taira T; Ariga H; Iguchi-Ariga S M (February 2000). "Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1(1)". FEBS Lett. NETHERLANDS. 467 (1): 1721.<br /><br />3. Ye, Q; Worman H J (June 1996). "Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1". J. Biol. Chem. UNITED STATES. 271(25): 146536.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001489-1	A01142	100 ug	-	$370		Add to Cart
BHA21001489-2	A01142-10ug	10 ug	Sample	$99		Add to Cart
BHA21001489-3	A01142-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21001489-4	A01142-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21001489-5	A01142-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21001489-6	A01142-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21001489-7	A01142-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21001489-8	A01142-FITC	100 ug	FITC	$570		Add to Cart
BHA21001489-9	A01142-HRP	100 ug	HRP	$570		Add to Cart
BHA21001489-10	A01142-APC	100 ug	APC	$670		Add to Cart
BHA21001489-11	A01142-PE	100 ug	PE	$670		Add to Cart
BHA21001489-12	A01142-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21001489-13	A01142-carrier-free	100 ug	carrier-free	$370		Add to Cart

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