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Home / Primary Antibodies / Polyclonal Antibodies

Anti-HMGCR Antibody Picoband®

SKU : BHA21004504

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Mfr.No.	A00643-3, A00643-3-10ug, A00643-3-Biotin, A00643-3-Cy3, A00643-3-Dylight488, A00643-3-Dylight550, A00643-3-Dylight594, A00643-3-FITC, A00643-3-HRP, A00643-3-APC, A00643-3-PE, A00643-3-iFluor647, A00643-3-carrier-free
Alternative Names	major vault protein
Background	HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the intealization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in tu increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alteatively spliced transcript variants encoding different isoforms have been found for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-HMGCR Antibody Picoband® catalog # A00643-3. Tested in ELISA, Flow Cytometry, IF, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling an
Host	Rabbit
Immunogen Region	E.coli-derived human HMGCR recombinant protein (Position: H268-V842).
Isotype	Rabbit IgG
Molecular Weight	97 kDa
Reactivity	Human
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Major vault protein; MVP; Lung resistance-related protein; MVP; LRP
Tissue Specificity	Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	P04035
Gene Id	3156
Gene Name	HMGCR
Subcellular Location	Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	ELISA, Flow Cytometry, IF, IHC, WB
Description	Weste blot, 0.25-0.5 ug/ml, Human Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human Immunofluorescence, 5 ug/ml, Human Flow Cytometry (Fixed), 1-3 ug/1x10⁶ cells, Human ELISA, 0.1-0.5 ug/ml, -

Reference	1. Aulchenko, Y. S., Ripatti, S., Lindqvist, I., Boomsma, D., Heid, I. M., Pramstaller, P. P., Penninx, B. W. J. H., Janssens, A. C. J. W., Wilson, W. F., Spector, T., Martin, N. G., Pedersen, N. L. {and 45 others}: Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nature Genet. 41: 47-55, 2009. 2. Chasman, D. I., Posada, D., Subrahmanyan, L., Cook, N. R., Stanton, V. P., Jr., Ridker, P. M. Pharmacogenetic study of statin therapy and cholesterol reduction. JAMA 291: 2821-2827, 2004. 3. Goldstein, J. L., Brown, M. S. Regulation of the mevalonate pathway. Nature 343: 425-430, 1990.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004504-1	A00643-3	-	100 ug	$370		Add to Cart
BHA21004504-2	A00643-3-10ug	Sample	10 ug	$99		Add to Cart
BHA21004504-3	A00643-3-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004504-4	A00643-3-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004504-5	A00643-3-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004504-6	A00643-3-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004504-7	A00643-3-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004504-8	A00643-3-FITC	FITC	100 ug	$570		Add to Cart
BHA21004504-9	A00643-3-HRP	HRP	100 ug	$570		Add to Cart
BHA21004504-10	A00643-3-APC	APC	100 ug	$670		Add to Cart
BHA21004504-11	A00643-3-PE	PE	100 ug	$670		Add to Cart
BHA21004504-12	A00643-3-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004504-13	A00643-3-carrier-free	carrier-free	100 ug	$370		Add to Cart

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