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Home / Primary Antibodies / IHC Antibodies

Anti-HMGB1 Antibody BHA11301011

SKU : BHA11301011

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Mfr.No.	BS1918
Alternative Names	High mobility group protein B1 ; High mobility group protein 1 ; HMG-1 ; HMGB1 ; HMG1
Categories	Primary Antibodies
Chromosome Location	13q12.3
Clonality	polyclonal
Description	High mobility group (HMG) proteins 1 and 2 are ubiquitous non-histone components of chromatin. Research suggests that the binding of HMG proteins to DNA induces alterations in the DNA architecture, including DNA bending and unwinding of the helix. HMG proteins synergize with Oct-2, ATF-2, c-Jun and members of the NFκB family to activate transcription. Additional studies indicate that phosphorylation of HMG protein is required to stimulate the transcriptional activity of the protein. Human HMG-1 and HMG-2 each contain two DNA-binding domains, termed HMG boxes. HMG proteins bind singlestranded DNA but induce conformational changes in double-stranded DNA alone.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 131-180 of Human HMGB1.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P09429
Uniprot	P09429
Weight	25 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2. Specificity: HMGB1 (A164) polyclonal antibody detects endogenous levels of HMGB1 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC, IF

Description

WB ; IHC ; IF

Dilution

WB	1:500-1:1000
IHC	1:50-1:200
IF	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11301011	BS1918	50µl	$190.44		Add to Cart
BHA11301011	BS1918	100µl	$294.44		Add to Cart

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