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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Histamine H3 receptor HRH3 Antibody Picoband®

SKU : BHA21006677

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Mfr.No.	PA1204, PA1204-10ug, PA1204-Biotin, PA1204-Cy3, PA1204-Dylight488, PA1204-Dylight550, PA1204-Dylight594, PA1204-FITC, PA1204-HRP, PA1204-APC, PA1204-PE, PA1204-iFluor647, PA1204-carrier-free
Alternative Names	Histamine H3 receptor
Background	The histamine receptor H3 (HRH3) is a presynaptic autoreceptor on histamine neurons in the brain and a presynaptic heteroreceptor in nonhistamine-containing neurons in both the central and peripheral nervous systems. The deduced 445-amino acid HRH3 protein contains 7 predicted transmembrane domains. And it shares 22% and 21.4% amino acid sequence homology with the H1 (HRH1) and H2 (HRH2) receptors, respectively. The expression of recombinant HRH3 in a variety of cell lines conferred an ability to inhibit adenylate cyclase in response to histamine, but not to acetylcholine or any other biogenic amine. Additionally, HRH3 was most notably observed throughout the thalamus, the ventromedial hypothalamus, and the caudate nucleus. Strong expression was also seen in layers II, V, and VIb of the cerebral cortex, in the pyramidal layers of the hippocampus, and in olfactory tubercle.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Histamine H3 receptor HRH3 Antibody catalog # PA1204. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist).
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human HRH3, different from the related rat sequence by three amino acids.
Isotype	Rabbit IgG
Molecular Weight	49 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Histamine H3 receptor;H3R;HH3R;G-protein coupled receptor 97;HRH3;GPCR97;
Tissue Specificity	Expressed predominantly in the CNS, with the greatest expression in the thalamus and caudate nucleus. The various isoforms are mainly coexpressed in brain, but their relative expression level varies in a region-specific manner. Isoform 3 and isoform 7 are highly expressed in the thalamus, caudate nucleus and cerebellum while isoform 5 and isoform 6 show a poor expression. Isoform 5 and isoform 6 show a high expression in the amygdala, substantia nigra, cerebral cortex and hypothalamus. Isoform 7 is not found in hypothalamus or substantia nigra.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q9Y5N1
Gene Name	HRH3
Subcellular Location	Cell membrane; Multi-pass membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. Hill, S. J.; Ganellin, C. R.; Timmerman, H.; Schwartz, J. C.; Shankley, N. P.; Young, J. M.; Schunack, W.; Levi, R.; Haas, H. L. : Inteational Union of Pharmacology. XIII. Classification of histamine receptors. Pharm. Rev. 49: 253-278, 1997.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006677-1	PA1204	-	100 ug	$370		Add to Cart
BHA21006677-2	PA1204-10ug	Sample	10 ug	$99		Add to Cart
BHA21006677-3	PA1204-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006677-4	PA1204-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006677-5	PA1204-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006677-6	PA1204-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006677-7	PA1204-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006677-8	PA1204-FITC	FITC	100 ug	$570		Add to Cart
BHA21006677-9	PA1204-HRP	HRP	100 ug	$570		Add to Cart
BHA21006677-10	PA1204-APC	APC	100 ug	$670		Add to Cart
BHA21006677-11	PA1204-PE	PE	100 ug	$670		Add to Cart
BHA21006677-12	PA1204-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006677-13	PA1204-carrier-free	carrier-free	100 ug	$370		Add to Cart

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