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Home / Primary Antibodies / Monoclonal Antibodies

Anti-Hemoglobin A

SKU : BHA15100371

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Mfr.No.	AM977-5M
Clonality	Monoclonal
Description	The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5?- zeta pseudozeta mu pseudoalpha-1 alpha-2 alpha-1 theta 3?. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical and only differ slightly over the 5? untranslated regions and the introns (although they differ significantly over the 3? untranslated regions). Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. A reduction in the production of normal alpha globin chains results in inherited hematologic disorders such as alpha thalassemia whereby there is an increase in beta chains to compensate for the lack of normal alpha globin chains. This alters the physiology of the red blood cell and results in the characteristic clinical and/or laboratory findings of the four types of alpha thalassemia. Pregnant persons with alpha thalassemia are considered a high risk given the dangers the disease poses to the mother and her unborn child. Along with Hemoglobin beta subunits, Hemoglobin A has been researched and found to be one of the serum biomarkers for diagnosis in ovarian cancer. The Hemoglobin A protein is expressed in lymphatic organs such as spleen and bone marrow. In spleen tissues, the hemoglobin alpha protein is expressed in the cytoplasm of red pulp cells and in bone marrow tissues it is expressed in the cytoplasm of hematopoietic cells.
Host	Mouse
Isotype	IgG
Reactivity	Human
Species	Mouse

Clone No	EPR3608
Research Area	Infectious diseases, Immune system

Buffer	PBS
Concentration	1-3ug/ml
Storage	2-8°C

Applications	IHC
Dilution	1:10-20

Product Manual	Datasheet SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
AM977-5M	AM977-5M	6 mL	$297		Add to Cart
AM977-10M	AM977-10M	100 tests - i6000	$526		Add to Cart
AX977-50D	AX977-50D	50 tests - Xmatrx	$314		Add to Cart
AX977-YCD	AX977-YCD	160 tests - Xmatrx	$846		Add to Cart
MU977-UC	MU977-UC	1ml Conc	$438		Add to Cart
MU977-5UC	MU977-5UC	0.5ml Conc	$302		Add to Cart

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