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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Heat shock protein beta-2 HSPB2 Antibody Picoband®

SKU : BHA21007070

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Mfr.No.	PA1802, PA1802-10ug, PA1802-Biotin, PA1802-Cy3, PA1802-Dylight488, PA1802-Dylight550, PA1802-Dylight594, PA1802-FITC, PA1802-HRP, PA1802-APC, PA1802-PE, PA1802-iFluor647, PA1802-carrier-free
Alternative Names	Heat shock protein beta-2
Background	Alpha-B-crystallin is a member of the alpha-crystallin/small heat-shock protein (HSP) family and under various neuropathologic conditions accumulates in reactive astrocytes and degenerating neurons. In the 5-prime flanking region of the CRYAB gene on 11q22-q23, where a constitutive DNaseI hypersensitive site is located, Iwaki et al. (1997) identified a gene transcribed in the opposite ion. Analysis of its mRNA structure by RT-PCR and 5-prime/3-prime RACE revealed that this gene is composed of 2 exons and encodes a new member of the alpha-crystallin/hsp family. They termed the gene HSPB2. Iwaki et al. (1997) also determined the complete genomic structure of the rat homolog of HSPB2. Southe blot analysis demonstrated that HSPB2is expressed preferentially in skeletal muscle and heart but not in the lens, while the neighboring CRYAB gene is highly expressed in all 3 tissues. The 2 related genes are arranged in a head-to-head manner with an intergenic sequence of less than 1 kb, raising a possibility of shared regulatory elements for their expression.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Heat shock protein beta-2 HSPB2 Antibody catalog # PA1802. Tested in IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	May regulate the kinase DMPK. .
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human HSPB2, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	23 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Heat shock protein beta-2;HspB2;DMPK-binding protein;MKBP;HSPB2;
Tissue Specificity	Expressed preferentially in skeletal muscle and heart but not in the lens.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q16082
Gene Name	HSPB2
Sequence	Belongs to the small heat shock protein (HSP20) family.
Subcellular Location	Cytoplasm . Nucleus . Localizes to nuclear foci.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br>Immunohistochemistry (Frozen Section), 0.5-1ug/ml, Rat, Human, Mouse<br>Immunocytochemistry , 0.5-1ug/ml, Human, Mouse, Rat<br>

Reference	1. Iwaki, A., Nagano, T., Nakagawa, M., Iwaki, T., Fukumaki, Y. Identification and characterization of the gene encoding a new member of the alpha-crystallin/Small hsp family, closely linked to the alpha-B-crystallin gene in a head-to-head manner. Genomics 45: 386-394, 1997.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007070-1	PA1802	-	100 ug	$370		Add to Cart
BHA21007070-2	PA1802-10ug	Sample	10 ug	$99		Add to Cart
BHA21007070-3	PA1802-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007070-4	PA1802-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007070-5	PA1802-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007070-6	PA1802-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007070-7	PA1802-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007070-8	PA1802-FITC	FITC	100 ug	$570		Add to Cart
BHA21007070-9	PA1802-HRP	HRP	100 ug	$570		Add to Cart
BHA21007070-10	PA1802-APC	APC	100 ug	$670		Add to Cart
BHA21007070-11	PA1802-PE	PE	100 ug	$670		Add to Cart
BHA21007070-12	PA1802-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007070-13	PA1802-carrier-free	carrier-free	100 ug	$370		Add to Cart

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