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Home / Primary Antibodies / Polyclonal Antibodies

Anti-HDAC11 Antibody Picoband®

SKU : BHA21000531

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Mfr.No.	PB9630, PB9630-10ug, PB9630-Biotin, PB9630-Cy3, PB9630-Dylight488, PB9630-Dylight550, PB9630-Dylight594, PB9630-FITC, PB9630-HRP, PB9630-APC, PB9630-PE, PB9630-iFluor647, PB9630-carrier-free
Alternative Names	Histone deacetylase 11
Background	Histone deacetylase 11 is a 39kDa histone deacetylase enzyme that in humans is encoded by the HDAC11 gene on chromosome 3 in humans and chromosome 6 in mice. This gene encodes a class IV histone deacetylase. And the encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alteative splicing results in multiple transcript variants. HDAC11 expression is normally found in brain and testis tissue, but upregulation of HDAC11 expression has also been seen in various cancer cells. In addition, HDAC11 has been shown to be a negative regulator of IL-10 production in antigen presenting cells. It has also been shown that inhibition of HDAC11 results in increased expression of OX40L in Hodgkin lymphoma cells.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-HDAC11 Antibody Picoband® catalog # PB9630. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progr
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human HDAC11, different from the related mouse sequence by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	37 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Histone deacetylase 11;HD11;3.5.1.98;HDAC11;
Tissue Specificity	Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testis.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q96DB2
Gene Id	79885
Gene Name	HDAC11
Sequence	Contains 1 HMG box DNA-binding domain.
Subcellular Location	Nucleus. Predominantly nuclear.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Mouse, Rat, Human, By Heat Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat

Reference	1. "Entrez Gene: HDAC11 histone deacetylase 11". 2. Gao L, Cueto MA, Asselbergs F, Atadja P (Jul 2002). "Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family".The Joual of Biological Chemistry 277(28): 2574855.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000531-1	PB9630	100 ug	-	$370		Add to Cart
BHA21000531-2	PB9630-10ug	10 ug	Sample	$99		Add to Cart
BHA21000531-3	PB9630-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000531-4	PB9630-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000531-5	PB9630-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000531-6	PB9630-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000531-7	PB9630-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000531-8	PB9630-FITC	100 ug	FITC	$570		Add to Cart
BHA21000531-9	PB9630-HRP	100 ug	HRP	$570		Add to Cart
BHA21000531-10	PB9630-APC	100 ug	APC	$670		Add to Cart
BHA21000531-11	PB9630-PE	100 ug	PE	$670		Add to Cart
BHA21000531-12	PB9630-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000531-13	PB9630-carrier-free	100 ug	carrier-free	$370		Add to Cart

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