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Home / Primary Antibodies / IHC Antibodies

Anti-GUCY1B1 Antibody BHA11300332

SKU : BHA11300332

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Mfr.No.	BS1158
Alternative Names	Guanylate cyclase soluble subunit beta-1 ; GCS-beta-1 ; Guanylate cyclase soluble subunit beta-3 ; GCS-beta-3 ; Soluble guanylate cyclase small subunit ; GUCY1B3 ; GUC1B3 ; GUCSB3 ; GUCY1B1 ; GCS-β1 ; GCS β1 ; GCSβ1 ; GCS-β3 ; GCS β3 ; GCSβ3 ; GCS-β-3
Antigen	GUCY1B1
Categories	Primary Antibodies
Chromosome Location	4q32.1
Clonality	polyclonal
Description	Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase, a soluble form (GCS or sGC), which act as receptors for nitric oxide and a membrane-bound receptor form (GC), which are peptide hormone receptors. The GC-C protein is composed of an extracellular domain, a single transmembrane domain, and a cytoplasmic region consisting of a kinase-like domain and a catalytic domain. It is expressed as two differentially glycosylated forms, a 130 kDa precursor form present in the endoplasmic reticulum and a 145 kDa form present on the plasma membrane. Ligand binding to the extracellular domain of GC-C promotes the accumulation of cGMP. GC-C acts as the receptor for heatstable enterotoxins, small peptides secreted by some pathogenic strains of E. coli that cause severe secretory diarrhea. GC-C also binds to guanylin and uroguanylin peptides, which modulate renal function in response to oral salt load.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to the N-terminus of Human GCS-β-1.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q02153
Uniprot	Q02153
Weight	70 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2. Specificity: GCS-β-1 (V21) polyclonal antibody detects endogenous levels of Guanylate Cyclase β1/3 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC, IP

Description

WB ; IHC ; IP

Dilution

WB	1:500-1:1000
IHC	1:50-1:200
IP	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11300332	BS1158	50µl	$190.44		Add to Cart
BHA11300332	BS1158	100µl	$294.44		Add to Cart

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