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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Glucose Transporter GLUT4/SLC2A4 Antibody Picoband®

SKU : BHA21007008

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Mfr.No.	PA1722, PA1722-10ug, PA1722-Biotin, PA1722-Cy3, PA1722-Dylight488, PA1722-Dylight550, PA1722-Dylight594, PA1722-FITC, PA1722-HRP, PA1722-APC, PA1722-PE, PA1722-iFluor647, PA1722-carrier-free
Alternative Names	Solute carrier family 2, facilitated glucose transporter member 4
Background	Facilitated glucose transport by mammalian cells is not a property of a single protein but an activity associated with a family of structurally related proteins. Glucose transporter 4 is a insulin-responsive glucose transporter. It belongs to solute carrier family 2, member 1. Insulin alters the subcellular localization of GLUT4 vesicles in human muscle, and that this effect is impaired equally in insulin-resistant subjects with and without diabetes. A similar patte of defects cause insulin resistance in human adipocytes.Human insulin resistance involves a defect in GLUT4 traffic and targeting leading to accumulation in a dense membrane compartment from which insulin is unable to recruit GLUT4 to the cell surface.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Glucose Transporter GLUT4/SLC2A4 Antibody catalog # PA1722. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Insulin-regulated facilitative glucose transporter.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human GLUT4, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	55 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Solute carrier family 2, facilitated glucose transporter member 4;Glucose transporter type 4, insulin-responsive;GLUT-4;SLC2A4;GLUT4;
Tissue Specificity	Skeletal and cardiac muscles; brown and white fat.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P14672
Gene Name	SLC2A4
Sequence	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Subcellular Location	Cell membrane ; Multi-pass membrane protein . Endomembrane system ; Multi-pass membrane protein . Cytoplasm, perinuclear region . Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reintealized. The dileucine intealization motif is critical for intracellular sequestration.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat, Mouse, By Heat<br>

Reference	1. Bibaum, M. J. : Identification of a novel gene encoding an insulin-responsive glucose transporter protein. Cell 57: 305-315, 1989. <br /><br />2. Bell, G. I.; Kayano, T.; Buse, J. B.; Burant, C. F.; Takeda, J.; Lin, D.; Fukumoto, H.; Seino, S. : Molecular biology of mammalian glucose transporters. Diabetes Care 13: 198-208, 1990. <br /><br />3. Garvey, W. T.; Maianu, L.; Zhu, J.-H.; Brechtel-Hook, G.; Wallace, P.; Baron, A. D. : Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance. J. Clin. Invest. 101: 2377-2386, 1998. <br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007008-1	PA1722	-	100 ug	$370		Add to Cart
BHA21007008-2	PA1722-10ug	Sample	10 ug	$99		Add to Cart
BHA21007008-3	PA1722-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007008-4	PA1722-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007008-5	PA1722-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007008-6	PA1722-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007008-7	PA1722-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007008-8	PA1722-FITC	FITC	100 ug	$570		Add to Cart
BHA21007008-9	PA1722-HRP	HRP	100 ug	$570		Add to Cart
BHA21007008-10	PA1722-APC	APC	100 ug	$670		Add to Cart
BHA21007008-11	PA1722-PE	PE	100 ug	$670		Add to Cart
BHA21007008-12	PA1722-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007008-13	PA1722-carrier-free	carrier-free	100 ug	$370		Add to Cart

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