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Home / Primary Antibodies / Polyclonal Antibodies

Anti-FOXP1 Antibody Picoband®

SKU : BHA21002919

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Mfr.No.	A00723, A00723-10ug, A00723-Biotin, A00723-Cy3, A00723-Dylight488, A00723-Dylight550, A00723-Dylight594, A00723-FITC, A00723-HRP, A00723-APC, A00723-PE, A00723-iFluor647, A00723-carrier-free
Alternative Names	Oithine carbamoyltransferase, mitochondrial
Background	FOXP1 ("forkhead box P1") is a gene that is necessary for the proper development of the brain and lung in mammals. It is a member of the large FOX family of transcription factors. This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene (s). Alteative splicing results in multiple transcript variants encoding different isoforms. It was shown that the embryonic stem cell (ESC)-specific isoform of FOXP1 stimulates the expression of transcription factor genes required for pluripotency, including OCT4, NANOG, NR5A2, and GDF3, while concomitantly repressing genes required for ESC differentiation. This isoform also promotes the maintenance of ESC pluripotency and contributes to efficient reprogramming of somatic cells into induced pluripotent stem cells. These results reveal a pivotal role for an Alteative splicing event in the regulation of pluripotency through the control of critical ESC-specific transcriptional programs (2).
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-FOXP1 Antibody Picoband® catalog # A00723. Tested in IHC, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human FOXP1, identical to the related mouse and rat sequences.
Isotype	Rabbit IgG
Molecular Weight	82 kDa
Reactivity	Human, Monkey, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	Oithine carbamoyltransferase, mitochondrial;2.1.3.3;Oithine transcarbamylase;OTCase;OTC;
Tissue Specificity	Mainly expressed in liver and intestinal mucosa.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	Q9H334
Gene Id	27086
Gene Name	FOXP1
Subcellular Location	Mitochondrion matrix.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB, IHC
Description	Weste blot, 0.25-0.5ug/ml, Human, Monkey<br> Immunohistochemistry (Paraffin-embedded Section), 1-2ug/ml, Human, Mouse, Rat<br>

Reference	1. Banham, A. H., Beasley, N., Campo, E., Feandez, P. L., Fidler, C., Gatter, K., Jones, M., Mason, D. Y., Prime, J. E., Trougouboff, P., Wood, K., Cordell, J. L.The FOXP1 winged helix transcription factor is a novel candidate tumor suppressor gene on chromosome 3p.Cancer Res. 61: 8820-8829, 2001.<br /><br />2. Feng, X., Ippolito, G. C., Tian, L., Wiehagen, K., Oh, S., Sambandam, A., Willen, J., Bunte, R. M., Maika, S. D., Harriss, J. V., Caton, A. J., Bhandoola, A., Tucker, P. W., Hu, H.Foxp1 is an essential transcriptional regulator for the generation of quiescent naive T cells during thymocyte development.Blood 115: 510-518, 2010.<br /><br />3. Shi, C., Sakuma, M., Mooroka, T., Liscoe, A., Gao, H., Croce, K. J., Sharma, A., Kaplan, D., Greaves, D. R., Wang, Y., Simon, D. I.Down-regulation of the forkhead transcription factor Foxp1 is required for monocyte differentiation and macrophage function.Blood 112: 4699-4711, 2008.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002919-1	A00723	-	100 ug	$370		Add to Cart
BHA21002919-2	A00723-10ug	Sample	10 ug	$99		Add to Cart
BHA21002919-3	A00723-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002919-4	A00723-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002919-5	A00723-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002919-6	A00723-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002919-7	A00723-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002919-8	A00723-FITC	FITC	100 ug	$570		Add to Cart
BHA21002919-9	A00723-HRP	HRP	100 ug	$570		Add to Cart
BHA21002919-10	A00723-APC	APC	100 ug	$670		Add to Cart
BHA21002919-11	A00723-PE	PE	100 ug	$670		Add to Cart
BHA21002919-12	A00723-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002919-13	A00723-carrier-free	carrier-free	100 ug	$370		Add to Cart

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