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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Follistatin-related protein 3 FSTL3 Antibody Picoband®

SKU : BHA21007159

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Mfr.No.	PA1915, PA1915-10ug, PA1915-Biotin, PA1915-Cy3, PA1915-Dylight488, PA1915-Dylight550, PA1915-Dylight594, PA1915-FITC, PA1915-HRP, PA1915-APC, PA1915-PE, PA1915-iFluor647, PA1915-carrier-free
Alternative Names	Follistatin-related protein 3
Background	FSTL3 (Follistatin-Like 3) also known as FLRG or FOLLISTATIN-RELATED GENE, is a member of the follistatin-module protein family, which is composed of extracellular matrix-associated glycoproteins though to act in a paracrine manner to bind morphogens or growth/differentiation factors and regulate their activity during development. The FSTL3 gene extends over 7 kbp and contains 5 exons. By Southe blot analysis of somatic cell hybrids and FISH, Hayette et al. (1998) localized the FSTL3 gene to chromosome 19p13. Using recombinant mouse Fstl3, Tsuchida et al. (2000) found that Fstl3bound both activin and BMP2 and had a higher affinity for activin. Overexpression of Fstl3 inhibited BMP2-induced cell signaling in a reporter assay. In addition to the translocation in a case of B-cell chronic lymphocytic leukemia from which FSTL3 was isolated, Hayette et al. (1998) also observed rearrangement of the FSTL3 gene in a case of B-cell non-Hodgkin lymphoma and in a case of B-cell mantle zone lymphoma, suggesting that FSTL3 may be involved in the leukemogenesis process.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Follistatin-related protein 3 FSTL3 Antibody catalog # PA1915. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activi
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human FSTL3, different from the related rat and mouse sequences by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	22-24 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Follistatin-related protein 3;Follistatin-like protein 3;Follistatin-related gene protein;FSTL3;FLRG;UNQ674/PRO1308;
Tissue Specificity	Expressed in a wide range of tissues. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	O95633
Gene Name	FSTL3
Sequence	Contains 2 follistatin-like domains.
Subcellular Location	Isoform 1: Secreted.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br>

Reference	1. Hayette, S., Gadoux, M., Martel, S., Bertrand, S., Tigaud, I., Magaud, J.-P., Rimokh, R. FLRG (follistatin-related gene), a new target of chromosomal rearrangement in malignant blood disorders.Oncogene 16: 2949-2954, 1998.<br /><br />2. Mukherjee, A., Sidis, Y., Mahan, A., Raher, M. J., Xia, Y., Rosen, E. D., Bloch, K. D., Thomas, M. K., Schneyer, A. L. FSTL3 deletion reveals roles for TGF-beta family ligands in glucose and fat homeostasis in adults. Proc. Nat. Acad. Sci. 104: 1348-1353, 2007.<br /><br />3. Tsuchida, K., Arai, K. Y., Kuramoto, Y., Yamakawa, N., Hasegawa, Y., Sugino, H. Identification and characterization of a novel follistatin-like protein as a binding protein for the TGF-beta family. J. Biol. Chem. 275: 40788-40796, 2000.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007159-1	PA1915	-	100 ug	$370		Add to Cart
BHA21007159-2	PA1915-10ug	Sample	10 ug	$99		Add to Cart
BHA21007159-3	PA1915-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007159-4	PA1915-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007159-5	PA1915-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007159-6	PA1915-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007159-7	PA1915-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007159-8	PA1915-FITC	FITC	100 ug	$570		Add to Cart
BHA21007159-9	PA1915-HRP	HRP	100 ug	$570		Add to Cart
BHA21007159-10	PA1915-APC	APC	100 ug	$670		Add to Cart
BHA21007159-11	PA1915-PE	PE	100 ug	$670		Add to Cart
BHA21007159-12	PA1915-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007159-13	PA1915-carrier-free	carrier-free	100 ug	$370		Add to Cart

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