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Home / Primary Antibodies / Polyclonal Antibodies

Anti-FMRP/FMR1 Antibody Picoband®

SKU : BHA21000603

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Mfr.No.	PB9703, PB9703-10ug, PB9703-Biotin, PB9703-Cy3, PB9703-Dylight488, PB9703-Dylight550, PB9703-Dylight594, PB9703-FITC, PB9703-HRP, PB9703-APC, PB9703-PE, PB9703-iFluor647, PB9703-carrier-free
Alternative Names	Fragile X mental retardation protein 1
Background	FMR1 (fragile X mental retardation 1) is a human gene that codes for a protein called fragile X mentalretardation protein, or FMRP. This protein, most commonly found in the brain, is essential for normal cognitive development and female reproductive function. Mutations of this gene can lead to fragile X syndrome, mental retardation, premature ovarian failure, autism, Parkinson's disease, developmental delays and other cognitive deficits. The protein encoded by this gene binds RNA and is associated with polysomes. Additionally, the encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alteatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-FMRP/FMR1 Antibody Picoband® catalog # PB9703. Tested in IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Translation repressor. Component of the CYFIP1-EIF4E- FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression (By similarity). RNA- binding protein that
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human FMRP, different from the related mouse and rat sequences by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	71-73 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Fragile X mental retardation protein 1;FMRP;Protein FMR-1;FMR1;
Tissue Specificity	Highest levels found in neurons, brain, testis, placenta and lymphocytes. Also expressed in epithelial tissues and at very low levels in glial cells. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q06787
Gene Id	2332
Gene Name	FMR1
Subcellular Location	Cytoplasm . Nucleus . Nucleus, nucleolus .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human

Reference	1. Verkerk AJ, Pieretti M, Sutcliffe JS, Fu YH, Kuhl DP, Pizzuti A, Reiner O, Richards S, Victoria MF, Zhang FP (May 1991). "Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome". Cell 65(5): 90514. 2. Verheij C, Bakker CE, de Graaff E, Keulemans J, Willemsen R, Verkerk AJ, Galjaard H, Reuser AJ, Hoogeveen AT, Oostra BA (June 1993). "Characterization and localization of the FMR-1 gene product associated with fragile X syndrome". Nature 363 (6431): 7224.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000603-1	PB9703	100 ug	-	$370		Add to Cart
BHA21000603-2	PB9703-10ug	10 ug	Sample	$99		Add to Cart
BHA21000603-3	PB9703-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000603-4	PB9703-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000603-5	PB9703-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000603-6	PB9703-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000603-7	PB9703-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000603-8	PB9703-FITC	100 ug	FITC	$570		Add to Cart
BHA21000603-9	PB9703-HRP	100 ug	HRP	$570		Add to Cart
BHA21000603-10	PB9703-APC	100 ug	APC	$670		Add to Cart
BHA21000603-11	PB9703-PE	100 ug	PE	$670		Add to Cart
BHA21000603-12	PB9703-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000603-13	PB9703-carrier-free	100 ug	carrier-free	$370		Add to Cart

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