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Home / Primary Antibodies / Polyclonal Antibodies

Anti-FMO3 Antibody Picoband®

SKU : BHA21007038

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Mfr.No.	PA1764, PA1764-10ug, PA1764-Biotin, PA1764-Cy3, PA1764-Dylight488, PA1764-Dylight550, PA1764-Dylight594, PA1764-FITC, PA1764-HRP, PA1764-APC, PA1764-PE, PA1764-iFluor647, PA1764-carrier-free
Alternative Names	Dimethylaniline monooxygenase (N-oxide-forming) 3
Background	FMO3 (Flavin-containing Monooxygenase 3) is an enzyme that in humans is encoded by the FMO3 gene. The mammalian flavin-containing monooxygenases (FMO) represent a multigene family whose gene products are localized in the endoplasmic reticulum of many tissues. The FMO3 gene contains 1 noncoding and 8 coding exons. The FMO3 gene is mapped on 1q24.3. Using quantitative RNase protection assays, FMO3 is present in low abundance in fetal liver and lung and in adult kidney and lung, and in much greater abundance in adult liver. By Weste blot analysis of human liver microsomal samples ranging from 8 weeks gestation to 18 years of age, FMO1 is the major fetal isoform and FMO3 is the major adult isoform. FMO3 was expressed at intermediate levels until 11 years of age when a gender-independent increase in FMO3 expression was observed during puberty. Sufferers of trimethylaminuria may display a reduced ability to metabolize substrates for FMO3 such as nicotine. FMO3 metabolizes a number of drugs, including amphetamine, clozapine, deprenyl, metamphetamine, tamoxifen, ethionamide, thiacetazone, and sulindac sulfide.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-FMO3 Antibody catalog # PA1764. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. It N-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. Plays an important role in the metabolism of trimethylamine (TMA), via t
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human FMO3, different from the related rat sequence by one amino acid, and from the related mouse sequence by two amino acids.
Isotype	Rabbit IgG
Molecular Weight	33 kDa
Reactivity	Rat, Mouse, Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Dimethylaniline monooxygenase (N-oxide-forming) 3;1.14.13.8;Dimethylaniline oxidase 3;FMO II;FMO form 2;Hepatic flavin-containing monooxygenase 3;FMO 3;Trimethylamine monooxygenase;1.14.13.148;FMO3;
Tissue Specificity	Liver.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P31513
Gene Name	FMO3
Sequence	Belongs to the FMO family.
Subcellular Location	Microsome membrane. Endoplasmic reticulum membrane.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Rat, Human, Mouse<br>

Reference	1. Akerman, B. R., Chow, L., Forrest, S., Youil, R., Cashman, J., Treacy, E. P. Mutations in the flavin-containing monoxygenase (sic) form 3 (FMO3) gene cause trimethylaminuria, fish odour syndrome. (Abstract) Am. J. Hum. Genet. 61 (suppl.): A53 only, 1997.<br /><br />2. Cashman, J. R., Zhang, J. Interindividual differences of human flavin-containing monooxygenase 3: genetic polymorphisms and functional variation. Drug Metab. Dispos. 30: 1043-1052, 2002.<br /><br />3. Dolphin, C. T., Janmohamed, A., Smith, R. L., Shephard, E. A., Phillips, I. R. Missense mutation in flavin-containing mono-oxygenase 3 gene, FMO3, underlies fish-odour syndrome. Nature Genet. 17: 491-494, 1997.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007038-1	PA1764	-	100 ug	$370		Add to Cart
BHA21007038-2	PA1764-10ug	Sample	10 ug	$99		Add to Cart
BHA21007038-3	PA1764-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007038-4	PA1764-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007038-5	PA1764-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007038-6	PA1764-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007038-7	PA1764-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007038-8	PA1764-FITC	FITC	100 ug	$570		Add to Cart
BHA21007038-9	PA1764-HRP	HRP	100 ug	$570		Add to Cart
BHA21007038-10	PA1764-APC	APC	100 ug	$670		Add to Cart
BHA21007038-11	PA1764-PE	PE	100 ug	$670		Add to Cart
BHA21007038-12	PA1764-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007038-13	PA1764-carrier-free	carrier-free	100 ug	$370		Add to Cart

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