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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Fibroblast growth factor 19 FGF19 Antibody Picoband®

SKU : BHA21006822

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Mfr.No.	PA1476, PA1476-10ug, PA1476-Biotin, PA1476-Cy3, PA1476-Dylight488, PA1476-Dylight550, PA1476-Dylight594, PA1476-FITC, PA1476-HRP, PA1476-APC, PA1476-PE, PA1476-iFluor647, PA1476-carrier-free
Alternative Names	Fibroblast growth factor 19
Background	FGF19, Fibroblast growth factor 19, is a protein that in humans is encoded by the FGF19 gene. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. The FGF19 gene is mapped to 11q13.3. The deduced 216-amino acid FGF19 protein contains asignal sequence and 2 cysteine residues that are conserved in the FGF family. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. FGF19 stimulates hepatic protein and glycogen synthesis but does not induce lipogenesis. The effects of FGF19 are independent of the activity of either insulin or the protein kinase Akt and, instead, are mediated through a mitogen-activated protein kinase signaling pathway that activates components of the protein translation machinery and stimulates glycogen synthase activity.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Fibroblast growth factor 19 FGF19 Antibody catalog # PA1476. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4. .
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human FGF19.
Isotype	Rabbit IgG
Molecular Weight	24 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Fibroblast growth factor 19;FGF-19;FGF19;UNQ334/PRO533;
Tissue Specificity	Expressed in fetal brain, cartilage, retina, and adult gall bladder. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	O95750
Gene Name	FGF19
Subcellular Location	Secreted.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Kir, S., Beddow, S. A., Samuel, V. T., Miller, P., Previs, S. F., Suino-Powell, K., Xu, H. E., Shulman, G. I., Kliewer, S. A. , Mangelsdorf, D. J.FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis.<br /><br />2. Ladher, R. K., Anakwe, K. U., Guey, A. L., Schoenwolf, G. C., Francis-West, P. H.Identification of synergistic signals initiating inner ear development.<br /><br />3. Nishimura, T., Utsunomiya, Y., Hoshikawa, M., Ohuchi, H., Itoh, N.Structure and expression of a novel human FGF, FGF-19, expressed in the fetal brain. Biochim. Biophys. Acta 1444: 148-151, 1999.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006822-1	PA1476	-	100 ug	$370		Add to Cart
BHA21006822-2	PA1476-10ug	Sample	10 ug	$99		Add to Cart
BHA21006822-3	PA1476-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006822-4	PA1476-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006822-5	PA1476-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006822-6	PA1476-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006822-7	PA1476-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006822-8	PA1476-FITC	FITC	100 ug	$570		Add to Cart
BHA21006822-9	PA1476-HRP	HRP	100 ug	$570		Add to Cart
BHA21006822-10	PA1476-APC	APC	100 ug	$670		Add to Cart
BHA21006822-11	PA1476-PE	PE	100 ug	$670		Add to Cart
BHA21006822-12	PA1476-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006822-13	PA1476-carrier-free	carrier-free	100 ug	$370		Add to Cart

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