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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Fibroblast activation protein, alpha/FAP Antibody Picoband®

SKU : BHA21004500

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Mfr.No.	A00422-5, A00422-5-10ug, A00422-5-Biotin, A00422-5-Cy3, A00422-5-Dylight488, A00422-5-Dylight550, A00422-5-Dylight594, A00422-5-FITC, A00422-5-HRP, A00422-5-APC, A00422-5-PE, A00422-5-iFluor647, A00422-5-carrier-free
Alternative Names	fibroblast activation protein alpha
Background	Fibroblast activation protein alpha (FAP-alpha) also known as prolyl endopeptidase FAP is an enzyme that in humans is encoded by the FAP gene. The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alteatively spliced transcript variants encoding different isoforms have been found for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Fibroblast activation protein, alpha/FAP Antibody Picoband® catalog # A00422-5. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling, fibrosis, wound healing, inflammation and tumor growth. Both plasma membrane and soluble f
Host	Rabbit
Immunogen Region	E.coli-derived human Fibroblast activation protein, alpha/FAP recombinant protein (Position: Q65-Q580).
Isotype	Rabbit IgG
Molecular Weight	97 kDa
Reactivity	Human
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Prolyl endopeptidase FAP
Tissue Specificity	Expressed in adipose tissue. Expressed in the dermal fibroblasts in the fetal skin. Expressed in the granulation tissue of healing wounds and on reactive stromal fibroblast in epithelial cancers. Expressed in activated fibroblast-like synoviocytes from inflamed synovial tissues. Expressed in activated hepatic stellate cells (HSC) and myofibroblasts from cirrhotic liver, but not detected in normal liver. Expressed in glioma cells (at protein level). Expressed in glioblastomas and glioma cells. Isoform 1 and isoform 2 are expressed in melanoma, carcinoma and fibroblast cell lines.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q12884
Gene Id	2191
Gene Name	FAP
Subcellular Location	Prolyl endopeptidase FAP: Cell surface.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, Flow Cytometry, ELISA
Description	Weste blot, 0.1-0.25 ug/ml, Human<br> Flow Cytometry (Fixed), 1-3 ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5 ug/ml, -<br>

Reference	1. Goldstein, L. A., Ghersi, G., Pineiro-Sanchez, M. L., Salamone, M., Yeh, Y., Flessate, D., Chen, W.-T. Molecular cloning of seprase: a serine integral membrane protease from human melanoma. Biochim. Biophys. Acta 1361: 11-19, 1997. <br /><br />2. Kraman, M., Bambrough, P. J., Aold, J. N., Roberts, E. W., Magiera, L., Jones, J. O., Gopinathan, A., Tuveson, D. A., Fearon, D. T. Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha. Science 330: 827-830, 2010. <br /><br />3. Mathew, S., Scanlan, M. J., Mohan Raj, B. K., Murty, V. V. V. S., Garin-Chesa, P., Old, L. J., Rettig, W. J., Chaganti, R. S. K. The gene for fibroblast activation protein alpha (FAP), a putative cell surface-bound serine protease expressed in cancer stroma and wound healing, maps to chromosome band 2q23. Genomics 25: 335-337, 1995.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004500-1	A00422-5	-	100 ug	$370		Add to Cart
BHA21004500-2	A00422-5-10ug	Sample	10 ug	$99		Add to Cart
BHA21004500-3	A00422-5-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004500-4	A00422-5-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004500-5	A00422-5-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004500-6	A00422-5-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004500-7	A00422-5-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004500-8	A00422-5-FITC	FITC	100 ug	$570		Add to Cart
BHA21004500-9	A00422-5-HRP	HRP	100 ug	$570		Add to Cart
BHA21004500-10	A00422-5-APC	APC	100 ug	$670		Add to Cart
BHA21004500-11	A00422-5-PE	PE	100 ug	$670		Add to Cart
BHA21004500-12	A00422-5-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004500-13	A00422-5-carrier-free	carrier-free	100 ug	$370		Add to Cart

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