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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Fanca/FAA Antibody Picoband®

SKU : BHA21004331

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Mfr.No.	A03662-2, A03662-2-10ug, A03662-2-Biotin, A03662-2-Cy3, A03662-2-Dylight488, A03662-2-Dylight550, A03662-2-Dylight594, A03662-2-FITC, A03662-2-HRP, A03662-2-APC, A03662-2-PE, A03662-2-iFluor647, A03662-2-carrier-free
Alternative Names	minichromosome maintenance complex component 5
Background	Fanconi anaemia, complementation group A, also known as FAA, FACA and FANCA, is a protein which in humans is encoded by the FANCA gene. Acts upstream of or within several processes, including gonad development; regulation of CD40 signaling pathway; and regulation of regulatory T cell differentiation. Predicted to be located in nucleoplasm. Predicted to be part of Fanconi anaemia nuclear complex. Is expressed in several structures, including gut; liver; lung; reproductive system; and spleen. Used to study Fanconi anemia complementation group A. Human ortholog(s) of this gene implicated in several diseases, including Fanconi anemia (multiple); acute myeloid leukemia; esophagus squamous cell carcinoma; ovarian disease (multiple); and skin melanoma. Orthologous to human FANCA (FA complementation group A).
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Fanca/FAA Antibody Picoband® catalog # A03662-2. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed throu
Host	Rabbit
Immunogen Region	E.coli-derived mouse Fanca/FAA recombinant protein (Position: E1272-F1439).
Isotype	Rabbit IgG
Molecular Weight	180 kDa
Reactivity	Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	DNA replication licensing factor MCM5; CDC46 homolog; P1-CDC46; MCM5; CDC46
Tissue Specificity	Ubiquitous.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q9JL70
Gene Id	14087
Gene Name	Fanca
Subcellular Location	Nucleus. Cytosol.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, Flow Cytometry, ELISA
Description	Weste blot, 0.25-0.5 ug/ml, Mouse, Rat<br> Flow Cytometry (Fixed), 1-3 ug/1x10<sup>6</sup> cells, Mouse<br> ELISA, 0.1-0.5 ug/ml, -<br>

Reference	1. Abu-Issa, R., Eichele, G., Youssoufian, H. Expression of the Fanconi anemia group A gene (Fanca) during mouse embryogenesis. Blood 94: 818-824, 1999.<br /><br />2. Bouchlaka, C., Abdelhak, S., Amouri, A., Ben Abid, H., Hadiji, S., Frikha, M., Ben Othman, T., Amri, F., Ayadi, H., Hachicha, M., Rebai, A., Saad, A., Dellagi, K., Tunisian Fanconi Anemia Study Group. Fanconi anemia in Tunisia: high prevalence of group A and identification of new FANCA mutations. J. Hum. Genet. 48: 352-361, 2003.<br /><br />3. Castella, M., Pujol, R., Callen, E., Trujillo, J. P., Casado, J. A., Gille, H., Lach, F. P., Auerbach, A. D., Schindler, D., Benitez, J., Porto, B., Ferro, T., and 20 others. Origin, functional role, and clinical impact of Fanconi anemia FANCA mutations. Blood 117: 3759-3769, 2011.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004331-1	A03662-2	-	100 ug	$370		Add to Cart
BHA21004331-2	A03662-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21004331-3	A03662-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004331-4	A03662-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004331-5	A03662-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004331-6	A03662-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004331-7	A03662-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004331-8	A03662-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21004331-9	A03662-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21004331-10	A03662-2-APC	APC	100 ug	$670		Add to Cart
BHA21004331-11	A03662-2-PE	PE	100 ug	$670		Add to Cart
BHA21004331-12	A03662-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004331-13	A03662-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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