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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Estrogen Receptor/ESR1 Antibody Picoband®

SKU : BHA21000098

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Mfr.No.	PB9192, PB9192-10ug, PB9192-Biotin, PB9192-Cy3, PB9192-Dylight488, PB9192-Dylight550, PB9192-Dylight594, PB9192-FITC, PB9192-HRP, PB9192-APC, PB9192-PE, PB9192-iFluor647, PB9192-carrier-free
Alternative Names	Estrogen receptor
Background	Estrogen receptor alpha (ER-alpha), also known as NR3A1, is one of two main types of estrogen receptor, a nuclear receptor that is activated by the sex hormone estrogen. Estrogen receptors are involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. In humans, ER-alpha is encoded by the gene ESR1 (Estrogen Receptor 1). It is mapped to 6q25.1. This gene is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, it also play a role in other tissues such as bone.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Estrogen Receptor/ESR1 Antibody Picoband® catalog # PB9192. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves eith
Host	Rabbit
Immunogen Region	E.coli-derived human Estrogen Receptor recombinant protein (Position: F425-V595). Human Estrogen Receptor shares 89% and 88% amino acid (aa) sequences identity with mouse and rat Estrogen Receptor, respectively.
Isotype	Rabbit IgG
Molecular Weight	66 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Estrogen receptor;ER;ER-alpha;Estradiol receptor;Nuclear receptor subfamily 3 group A member 1;ESR1;ESR, NR3A1;
Tissue Specificity	Widely expressed. Isoform 3 is not expressed in the pituitary gland. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P03372
Gene Id	2099
Gene Name	ESR1
Sequence	Belongs to the nuclear hormone receptor family. NR3 subfamily.
Subcellular Location	Isoform 1: Nucleus . Cytoplasm . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . A minor fraction is associated with the inner membrane.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat Weste blot, 0.1-0.5ug/ml, Human

Reference	1. "Entrez Gene: ESR1 estrogen receptor 1" 2. Walter P, Green S, Greene G, Krust A, Boert JM, Jeltsch JM, Staub A, Jensen E, Scrace G, Waterfield M (December 1985). "Cloning of the human estrogen receptor cDNA". Proc. Natl. Acad. Sci. U.S.A. 82 (23): 788993. 3. Greene GL, Gilna P, Waterfield M, Baker A, Hort Y, Shine J (March 1986). "Sequence and expression of human estrogen receptor complementary DNA". Science 231 (4742): 11504.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000098-1	PB9192	100 ug	-	$370		Add to Cart
BHA21000098-2	PB9192-10ug	10 ug	Sample	$99		Add to Cart
BHA21000098-3	PB9192-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000098-4	PB9192-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000098-5	PB9192-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000098-6	PB9192-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000098-7	PB9192-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000098-8	PB9192-FITC	100 ug	FITC	$570		Add to Cart
BHA21000098-9	PB9192-HRP	100 ug	HRP	$570		Add to Cart
BHA21000098-10	PB9192-APC	100 ug	APC	$670		Add to Cart
BHA21000098-11	PB9192-PE	100 ug	PE	$670		Add to Cart
BHA21000098-12	PB9192-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000098-13	PB9192-carrier-free	100 ug	carrier-free	$370		Add to Cart

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