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Home / Primary Antibodies / Polyclonal Antibodies

Anti-ErbB 3/ERBB3 Antibody Picoband®

SKU : BHA21007136

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Mfr.No.	PA1880, PA1880-10ug, PA1880-Biotin, PA1880-Cy3, PA1880-Dylight488, PA1880-Dylight550, PA1880-Dylight594, PA1880-FITC, PA1880-HRP, PA1880-APC, PA1880-PE, PA1880-iFluor647, PA1880-carrier-free
Alternative Names	Receptor tyrosine-protein kinase erbB-3
Background	ERBB3 (V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3) also known as ONCOGENE ERBB3 or HER3, is an enzyme that in humans is encoded by the ERBB3 gene. This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. By in situ hybridization, Kraus et al. (1989) mapped the ERBB3 gene to chromosome 12q13. Carraway et al. (1994) demonstrated that ERBB3 is a receptor for heregulin and is capable of mediating HGL-stimulated tyrosine phosphorylation of itself. Most notably, EGFR and ErbB2 became markedly more promiscuous as the threshold was lowered, whereas ErbB3did not. Engelman et al. (2007) found that amplification of MET caused gefitinib resistance by driving ERBB3-dependent activation of phosphoinositide 3-kinase, a pathway though to be specific to EGFR/ERBB family receptors.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-ErbB 3/ERBB3 Antibody catalog # PA1880. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Binds and is activated by neuregulins and NTAK. May also be activated by CSPG5. .
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human ErbB 3.
Isotype	Rabbit IgG
Molecular Weight	180 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Receptor tyrosine-protein kinase erbB-3;2.7.10.1;Proto-oncogene-like protein c-ErbB-3;Tyrosine kinase-type cell surface receptor HER3;ERBB3;HER3;
Tissue Specificity	Epithelial tissues and brain.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P21860
Gene Name	ERBB3
Sequence	Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
Subcellular Location	Isoform 1: Cell membrane; Single-pass type I membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Carraway, K. L., III, Sliwkowski, M. X., Akita, R., Platko, J. V., Guy, P. M., Nuijens, A., Diamonti, A. J., Vandlen, R. L., Cantley, L. C., Cerione, R. A. The erbB3gene product is a receptor for heregulin. J. Biol. Chem. 269: 14303-14306, 1994.<br /><br />2. Engelman, J. A., Zejnullahu, K., Mitsudomi, T., Song, Y., Hyland, C., Park, J. O., Lindeman, N., Gale, C.-M., Zhao, X., Christensen, J., Kosaka, T., Holmes, A. J., Rogers, A. M., Cappuzzo, F., Mok, T., Lee, C., Johnson, B. E., Cantley, L. C, Janne, P. A. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 316: 1039-1043, 2007.<br /><br />3. Kraus, M. H., Issing, W., Miki, T., Popescu, N. C., Aaronson, S. A. Isolation and characterization ofERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. Proc. Nat. Acad. Sci. 86: 9193-9197, 1989.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007136-1	PA1880	-	100 ug	$370		Add to Cart
BHA21007136-2	PA1880-10ug	Sample	10 ug	$99		Add to Cart
BHA21007136-3	PA1880-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007136-4	PA1880-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007136-5	PA1880-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007136-6	PA1880-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007136-7	PA1880-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007136-8	PA1880-FITC	FITC	100 ug	$570		Add to Cart
BHA21007136-9	PA1880-HRP	HRP	100 ug	$570		Add to Cart
BHA21007136-10	PA1880-APC	APC	100 ug	$670		Add to Cart
BHA21007136-11	PA1880-PE	PE	100 ug	$670		Add to Cart
BHA21007136-12	PA1880-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007136-13	PA1880-carrier-free	carrier-free	100 ug	$370		Add to Cart

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