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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Eph receptor B3/EPHB3 Antibody Picoband®

SKU : BHA21006895

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Mfr.No.	PA1569, PA1569-10ug, PA1569-Biotin, PA1569-Cy3, PA1569-Dylight488, PA1569-Dylight550, PA1569-Dylight594, PA1569-FITC, PA1569-HRP, PA1569-APC, PA1569-PE, PA1569-iFluor647, PA1569-carrier-free
Alternative Names	Ephrin type-B receptor 3
Background	Ephrin Receptor EphB3, is also known as human embryo kinase2 (HEK2) or Eph-like tyrosine kinase2 (ETK2). HEK2, which is a member of the EPH/ELK family of tyrosine kinases, encodes a 998-amino acid polypeptide having a single putative transmembrane domain, a secretory signal sequence, and 2 fibronectin repeats. The EPHB3 gene is mapped to human chromosome 3q21-qter. HEK2 interacts with 2 ligands of EPH-related kinases (LERKs), namely, LERK2 (EFNB1) and LERK5 (EFNB2). Coincubation of HEK2- and LERK2-expressing cells induces cell-cell adhesion and aggregation. Additionally, coexpression of HEK2 and LERK2 results in reduced kinase activity of HEK2.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Eph receptor B3/EPHB3 Antibody catalog # PA1569. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent biional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Eph receptor B3, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	130 kDa
Reactivity	Rat, Mouse, Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Ephrin type-B receptor 3;2.7.10.1;EPH-like tyrosine kinase 2;EPH-like kinase 2;Embryonic kinase 2;EK2;hEK2;Tyrosine-protein kinase TYRO6;EPHB3;ETK2, HEK2, TYRO6;
Tissue Specificity	Ubiquitous.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P54753
Gene Name	EPHB3
Sequence	Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Subcellular Location	Cell membrane ; Single-pass type I membrane protein . Cell projection, dendrite .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat, Mouse, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. Bohme, B., Holtrich, U., Wolf, G., Luzius, H., Grzeschik, K.-H., Strebhardt, K., Rubsamen-Waigmann, H.PCR mediated detection of a new human receptor-tyrosine-kinase, HEK 2.Oncogene 8: 2857-2862, 1993. <br /><br />2. Bohme, B., VandenBos, T., Cerretti, D. P., Park, L. S., Holtrich, U., Rubsamen-Waigmann, H., Strebhardt, K.Cell-cell adhesion mediated by binding of membrane-anchored ligand LERK-2 to the EPH-related receptor human embryonal kinase 2 promotes tyrosine kinase activity.J. Biol. Chem. 271: 24747-24752, 1996.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006895-1	PA1569	-	100 ug	$370		Add to Cart
BHA21006895-2	PA1569-10ug	Sample	10 ug	$99		Add to Cart
BHA21006895-3	PA1569-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006895-4	PA1569-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006895-5	PA1569-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006895-6	PA1569-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006895-7	PA1569-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006895-8	PA1569-FITC	FITC	100 ug	$570		Add to Cart
BHA21006895-9	PA1569-HRP	HRP	100 ug	$570		Add to Cart
BHA21006895-10	PA1569-APC	APC	100 ug	$670		Add to Cart
BHA21006895-11	PA1569-PE	PE	100 ug	$670		Add to Cart
BHA21006895-12	PA1569-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006895-13	PA1569-carrier-free	carrier-free	100 ug	$370		Add to Cart

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